组织工程与重建外科杂志2024，Vol.20Issue(4)：434-439,6.DOI:10.3969/j.issn.1673-0364.2024.04.007
口服西罗莫司治疗腹腔淋巴管畸形的临床效果及预后
Clinical effects and prognosis of oral sirolimus in the treatment of abdominal lymphatic malformations
徐振国 1陈涛 1邰茂众 1葛春晓 1张秋琪 2李克雷1
作者信息
- 1. 276000 山东省临沂市临沂市肿瘤医院血管瘤特色专科
- 2. 276000 山东省临沂市临沂市肿瘤医院乳腺一科
- 折叠
摘要
Abstract
Objective To observe the clinical effect and prognosis of oral sirolimus in the treatment of abdominal lymphatic malformations.Methods From March 2020 to August 2022,clinical data of 5 patients with abdominal lymphatic malformations treated with oral sirolimus were retrospectively analyzed.Results All patients had abdominal pain before admission and were treated with oral sirolimus for 2 years.Subjective evaluation of clinical symptom improvement:Progress in 0 case,stability in 2 cases,improvement in 3 cases,cure in 0 case.Objective evaluation of lesion improvement:Grade Ⅰ(poor)in 2 cases,grade Ⅱ(medium)in 0 cases,grade Ⅲ(good)in 1 case,grade Ⅳ(excellent)in 2 cases.During the treatment,2 patients developed oral ulcers and 1 patients developed mild anemia,all of which were improved after symptomatic treatment.All patients had no serious complication.After 1 year of follow-up,abdominal pain and other symptoms did not appear again,and the tumors of 3 cases(macrocystic lymphatic malformations)were significantly reduced,and 2 cases(microcystic lymphatic malformations)did not show significant tumor growth.Conclusion Sirolimus is safe and effective in the treatment of abdominal lymphatic malformations,and can significantly relieve abdominal discomfort symptoms,especially for macrocystic lymphatic malformations,with significant tumor size reduction and satisfactory results.关键词
腹腔淋巴管畸形/西罗莫司/靶向治疗Key words
Abdominal lymphatic malformation/Sirolimus/Targeted therapy分类
医药卫生引用本文复制引用
徐振国,陈涛,邰茂众,葛春晓,张秋琪,李克雷..口服西罗莫司治疗腹腔淋巴管畸形的临床效果及预后[J].组织工程与重建外科杂志,2024,20(4):434-439,6.
