Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular DiseasesOACSTPCDEI
The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug ad…查看全部>>
Qingdong Bao;Xiaoting Zhang;Zhankun Hao;Qinghua Li;Fan Wu;Kaiyuan Wang;Yang Li;Wenlong Li;Hua Gao
State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,People’s Republic of China Eye Hospital of Shandong First Medical University,Jinan 250021,People’s Republic of China College of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of ChinaState Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,People’s Republic of ChinaCollege of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of ChinaState Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,People’s Republic of China Eye Hospital of Shandong First Medical University,Jinan 250021,People’s Republic of China College of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of ChinaCollege of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of ChinaDepartments of Diagnostic Radiology,Surgery,Chemical and Biomolecular Engineering,and Biomedical Engineering,Yong Loo Lin School of Medicine and College of Design and Engineering,National University of Singapore,Singapore 119074,SingaporeState Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,People’s Republic of ChinaState Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,People’s Republic of China Eye Hospital of Shandong First Medical University,Jinan 250021,People’s Republic of China College of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of ChinaState Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,People’s Republic of China Eye Hospital of Shandong First Medical University,Jinan 250021,People’s Republic of China College of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of China
临床医学
Ocular deliveryPolysaccharideMicroneedlesDrug administration
《Nano-Micro Letters》 2024 (12)
P.233-284,52
supported by the National Natural Science Foundation of China(82371032,82070923)the Major Basic Research Project of the Natural Science Foundation of Shandong Province(ZR2023ZD60)the Taishan Scholar Program(20231255)the Academic Promotion Program of Shandong First Medical University(2019RC009).