Antidepressant effects of Yuanzhi (Polygalae Radix) extract on chronic unpredictable mild stress-induced depression in rats: modulation of the NLRP3 inflammasome and NF-κB pathwayOA
Objective To investigate the antidepressant effects of Yuanzhi(Polygalae Radix;PR)aqueous extract on chronic unpredictable mild stress(CUMS)-induced depression rat models and the underlying mechanisms.Methods A total of 40 ma…查看全部>>
CHEN Yuzhen;ZHAO Yongzhi;ZHANG Yiwen;CHEN Fang;Iqbal Choudhary Muhammad;LIU Xinmin;JIANG Ning
Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China Hunan Engineering and Technology Research Center of Medicinal and Edible Homologous Functional Food,Hunan University of Chinese Medicine,Changsha,Hunan 410208,ChinaHunan Engineering and Technology Research Center of Medicinal and Edible Homologous Functional Food,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China Pharmay School of Shihezi University/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization,Ministry of Education,Shihezi,Xinjiang 832003,ChinaInstitute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,ChinaInstitute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China Hunan Engineering and Technology Research Center of Medicinal and Edible Homologous Functional Food,Hunan University of Chinese Medicine,Changsha,Hunan 410208,ChinaInternational Center for Chemical and Biological Sciences,University of Karachi,Karachi,Sandh 75270,PakistanInstitute of Drug Discovery Technology,Ningbo University,Ningbo,Zhejiang 315211,ChinaInstitute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China
中医学
DepressionYuanzhi(Polygalae Radix)Chronic unpredictable mild stress(CUMS)Proinflammatory cytokineNeuroinflammatory
《Digital Chinese Medicine》 2024 (2)
P.184-194,11
International Cooperative Project of Traditional Chinese Medicine(GZYYG2020023)CAMS Innovation Fund for Medical Sciences(CIFMS)Grant(2021-I2M-1-034)Key Research Project of Hunan Province(222SK2018).
评论