Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR lociOA
Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci
Short tandem repeats(STRs)are the most common genetic markers in forensic and human population genetics due to their high polymorphism,rapid detection,and reliable genotyping.To adapt the rapid growth of forensic DNA database and solve problems in disputed cases,a panel of 23 autosomal STR loci with high discriminating ability was constructed recently.The Tai-Kadai-speaking Gelao is the most ancient indigenous minority in Guizhou province,however,the forensic efficiency and population genetic structure remain poorly explored.Here,490 Guizhou Gelao individuals from Southwest China were genotyped with the panel of 23 STRs using the Huaxia Platinum Kit.A total of 265 alleles were screened.The combined discrimination power and the combined probability of paternity were 0.9999 and 0.9999,respectively.This indicated the 23 loci had higher discrimination power in Guizhou Gelao and could be applied to forensic practice.Comprehensive population structures with reference populations from China and abroad using the neighbour-joining phylogenetic tree(N-J tree),multidimensional scaling,principal component analysis and heatmap demonstrated that Guizhou Gelao was genetically closer to Guizhou Han than other populations.Moreover,our results showed that a complex phylogenetic model was influenced by ethnic,geographic,and linguistic factors.
Siyu Chai;Pengyu Chen;Shuhua Li;Ruxin Zhu;Li Luo;Kaiqin Chen;Yinlei Lei;Weihong Wan;Xijie Hu;Shiquan Liu
Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Shanghai,China||Center of Forensic Expertise,Affiliated hospital of Zunyi Medical University,Zunyi,ChinaKey Laboratory of Cell Engineering of Guizhou Province,Clinical Stem Cell Research Institute,Affiliated Hospital of Zunyi Medical University,Zunyi,China||Collaborative Innovation Center of Chinese Ministry of Education,Zunyi Medical University,Zunyi,China||Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Shanghai,China||Center of Forensic Expertise,Affiliated hospital of Zunyi Medical University,Zunyi,ChinaKey Laboratory of Cell Engineering of Guizhou Province,Clinical Stem Cell Research Institute,Affiliated Hospital of Zunyi Medical University,Zunyi,China||Collaborative Innovation Center of Chinese Ministry of Education,Zunyi Medical University,Zunyi,China||Center of Forensic Expertise,Affiliated hospital of Zunyi Medical University,Zunyi,ChinaShanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Shanghai,ChinaCenter of Forensic Expertise,Affiliated hospital of Zunyi Medical University,Zunyi,China||School of forensic medicine,Shanxi Medical University,Taiyuan,ChinaKey Laboratory of Cell Engineering of Guizhou Province,Clinical Stem Cell Research Institute,Affiliated Hospital of Zunyi Medical University,Zunyi,China||Collaborative Innovation Center of Chinese Ministry of Education,Zunyi Medical University,Zunyi,China||Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Shanghai,ChinaKey Laboratory of Cell Engineering of Guizhou Province,Clinical Stem Cell Research Institute,Affiliated Hospital of Zunyi Medical University,Zunyi,China||Collaborative Innovation Center of Chinese Ministry of Education,Zunyi Medical University,Zunyi,ChinaInstitute of Evidence Law and Forensic Science,China University of Political Science and Law,Beijing,China
short tandem repeatsGuizhou Gelaogenetic polymorphismspopulation structure
《法庭科学研究（英文）》 2024 (002)
41-48 / 8
This work was supported by Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Open Project(No.KF202109);National Natural Science Foundation(No.81401562);Science and Technology Project of Guizhou Provincial Health Commission(No.gzwkj2021-533);Science and Technology Cooperation Project of Zunyi Science and Technology and big data Bureau(No.HZ-2022-237);Science and Technology Foundation of Guizhou Province of China(No.QKHJC-ZK[2023]582).
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