国际神经病学神经外科学杂志2024，Vol.51Issue(4)：69-76,8.DOI:10.16636/j.cnki.jinn.1673-2642.2024.04.012
焦亡机制及其在胶质瘤中的作用研究进展
Research advances in the mechanism of pyroptosis and its role in glioma
王旭东 1梁强 2周景寰 1孙超 1潘亚文3
作者信息
- 1. 兰州大学第二临床医学院,甘肃兰州 730030||兰州大学第二医院神经病学研究所,甘肃兰州 730030
- 2. 兰州大学第二医院神经外科,甘肃兰州 730030||兰州大学第二医院神经病学研究所,甘肃兰州 730030
- 3. 兰州大学第二临床医学院,甘肃兰州 730030||兰州大学第二医院神经外科,甘肃兰州 730030||兰州大学第二医院神经病学研究所,甘肃兰州 730030
- 折叠
摘要
Abstract
Glioma is the most common malignant tumor of the central nervous system,and it is of great significance to explore effective diagnosis and treatment strategies.Pyroptosis,as a new pattern of inflammatory programmed cell death,has been extensively studied in glioma to reveal its process and mechanism.This article reviews the molecular mechanisms of pyroptosis,including the pathway of inflammasome activation,the Gasdermin family that performs pyroptosis,and the application and challenges of pyroptosis-related pathways and targets in the development,diagnosis,and treatment of glioma,so as to explore new treatment strategies for glioma through pyroptosis and improve the prognosis of patients.关键词
胶质瘤/焦亡/炎症小体/分子机制Key words
glioma/pyroptosis/inflammasome/molecular mechanism分类
医药卫生引用本文复制引用
王旭东,梁强,周景寰,孙超,潘亚文..焦亡机制及其在胶质瘤中的作用研究进展[J].国际神经病学神经外科学杂志,2024,51(4):69-76,8.
