国际神经病学神经外科学杂志2024，Vol.51Issue(4)：77-84,8.DOI:10.16636/j.cnki.jinn.1673-2642.2024.04.013
Wnt/β-catenin通路在成人胶质瘤中的作用研究进展
Research advances in the role of the Wnt/β-catenin pathway in adult glioma
摘要
Abstract
Glioma is the most common malignant tumor of the central nervous system,and it often originates from genetic mutations in cells.Studies have shown that the growth of a cell with a gene mutation into a malignant tumor cell with all phenotypes requires an abnormal development process involving cell proliferation,differentiation,stemness,and cell-cell interactions.In this process,tumor cells"commandeer"a large number of regulatory signaling pathways for normal development,including the Wnt/β-catenin signaling pathway,which is a highly conserved signaling pathway during evolution that mediates the interaction between adjacent cells and is widely involved in the precise regulation of normal development and the development and progression of malignant tumors.This article reviews the Wnt/β-catenin signaling pathway and its role and mechanism in glioma and describes the prospect of the Wnt/β-catenin signaling pathway as a target for the intervention and treatment of glioma.关键词
胶质瘤/Wnt/β-catenin信号通路/治疗Key words
glioma/Wnt/β-catenin signaling pathway/treatment分类
医药卫生引用本文复制引用
李硕,张刚利..Wnt/β-catenin通路在成人胶质瘤中的作用研究进展[J].国际神经病学神经外科学杂志,2024,51(4):77-84,8.基金项目
山西省基础研究计划项目(202203021211060). （202203021211060）
