军事医学2024，Vol.48Issue(8)：594-600,7.DOI:10.7644/j.issn.1674-9960.2024.08.006
人类红系分化相关基因对慢性炎症诱导的造血干细胞损伤的保护作用
EDAG protects hematopoietic stem cells from damage induced by chronic inflammation
摘要
Abstract
Objective To investigate the effect of erythroid differentiation associated gene(EDAG)on hematopoietic stem/progenitor cells(HSPCs)under chronic inflammation.Methods In this study,EDAG-/-and wild type(WT)mice were divided into the experiment group and control group.An infectious chronic inflammation model was established via multiple intraperitoneal injections of Listeria monocytogenes(LM),while a sterile chronic inflammation model was generated via multiple intraperitoneal injections of polyinosinic-polycytidylic acid[Poly(I∶C)].The effect of EDAG on HSPCs was explored under chronic inflammation conditions.Results In the LM repeated infection model,EDAG deletion led to a decrease in HSPCs and long-term hematopoietic stem cells(LT-HSCs)in mice as well as a significant bias towards myeloid differentiation in peripheral blood.Similarly,EDAG knockout also resulted in reduced numbers of HSPCs and decreased colony-forming ability in aseptic chronic inflammation models.Conclusion EDAG deficiency accelerates HSPC depletion in young mice under chronic inflammation,indicating strong protection of EDAG against HSPC damage induced by chronic inflammation.关键词
红系分化相关基因/慢性炎症/造血干/祖细胞/耗竭/衰老Key words
erythroid differentiation associated gene/chronic inflammation/hematopoietic stem/progenitor cells/exhaustion/aging分类
医药卫生引用本文复制引用
李思雨,李长燕,赵珂,武云强,吕志春,孙慧颖,赵雄伟,薛阳,高慧英,向慎思..人类红系分化相关基因对慢性炎症诱导的造血干细胞损伤的保护作用[J].军事医学,2024,48(8):594-600,7.基金项目
国家自然科学基金面上项目(82370115) （82370115）
