临床口腔医学杂志2024，Vol.40Issue(9)：559-563,5.DOI:10.3969/j.issn.1003-1634.2024.09.011
牙周炎与慢性胃炎或胃溃疡之间的因果关系:双向双孟德尔随机化分析
Periodontitis and chronic gastritis or gastric ulcers:a two-sample Mendelian randomization analysis
摘要
Abstract
Objective:This study set out to look into the causal relationship between periodontitis(PD)and either chronic gastritis(CG)or gastric ulcers(GU)by a two-sample bidirectional Mendelian randomization study.Methods:Genome-wide association study(GWAS)data of PD was obtained from Gene-Lifestyle Interactions in Dental Endpoints(GLIDE)(12289 cases).The FinnGen consortium provided the GWAS data on CG(7605 cases)and GU(4542 cases).The analysis was conducted mostly using the inverse-variance weighted(IVW)approach.To identify and account for the impact of horizon-tal pleiotropy,three different methods were used:weighted median(WM),MR Egger regression,and MR pleiotropy residual sum and outlier(MR-PRESSO).Results:IVW method established that PD had no causal effect on CG(OR=0.885,95%CI:0.725～1.081,P=0.234)and GU(OR=1.034,95%CI:0.860～1.244,P=0.720).Similarly,neither CG nor GU had a sig-nificant causal influence on PD.The outcomes of the MR-Egger and weighted median were in accordance with the IVW ap-proach.Conclusion:PD and chronic gastritis or stomach ulcers are not causally related to one another,and vice versa.关键词
牙周炎/慢性胃炎/胃溃疡/因果关系/孟德尔随机化Key words
Periodontitis/Chronic gastritis/Gastric ulcers/Causal relationship/Mendelian randomization分类
医药卫生引用本文复制引用
胡媛媛,沈萌璇,陆雨郡,黄昌骏,蔡扬,王亚静..牙周炎与慢性胃炎或胃溃疡之间的因果关系:双向双孟德尔随机化分析[J].临床口腔医学杂志,2024,40(9):559-563,5.基金项目
国家自然科学基金项目(82260200) （82260200）
贵州省自然科学基金项目(ZK[2021]436) （ZK[2021]436）
贵州医科大学科学基金项目(20NSP081) （20NSP081）
