新生儿期Kasai手术治疗胆道闭锁疗效观察OA北大核心CSTPCD

Objective To compare the clinical efficacy of Kasai procedure for biliary atresia(BA)between neonatal and non-neonatal periods.Methods From January 2018 to August 2022,the relevant clinical data were retrospectively reviewed for 52 hospitalized BA children.There were 24 boys(46.2％)and 28 girls(53.8％).Medi-an age at admission was 32.5(6.0,57.0)day,median age at surgery 37.0(12.0,58.0)day and mean preoperative body weight(3992.6±685.1)gram.The clinical efficacy of Kasai procedure for BA in neonatal period was analyzed by comparing operative findings,postoperative jaundice clearance and survival of autologous liver.Results All of them underwent Kasai procedure.Median postoperative hospitalization stay was 15.0 day and median follow-up period 37.5(14-66)month.At Month 6 post-Kasai,clearance rate of jaundice was higher in neonatal group than that in non-neonatal group(66.7％vs.58.6％).And 1-year native liver survival rate after Kasai operation was higher in neonatal group than that in non-neonatal group(66.7％vs.63.2％).Conclusions Kasai procedure during neonatal period is both safe and effective.When BA is suspected in neonatal period,surgical exploration should be performed as soon as possible to confirm the diagnosis and perform Kasai procedure.