日用化学工业（中英文）2024，Vol.54Issue(9)：1099-1105,7.DOI:10.3969/j.issn.2097-2806.2024.09.011
酵母菌/锌发酵产物在头皮护理中的功效研究
Study on the efficacy of yeast/zinc fermentation products in scalp care
尤孝鹏 1彭宁 2陈智仙2
作者信息
- 1. 农业微生物资源发掘与利用全国重点实验室,湖北 宜昌 443003||酵母功能湖北省重点实验室,湖北 宜昌 443003
- 2. 农业微生物资源发掘与利用全国重点实验室,湖北 宜昌 443003||酵母功能湖北省重点实验室,湖北 宜昌 443003||宜昌市营养健康食品工程技术研究中心,湖北 宜昌 443003
- 折叠
摘要
Abstract
The efficacy of yeast/zinc fermentation products in scalp care were studied from the aspects of safety,oil control and dandruff removal,and hair follicle maintenance.The safety of yeast/zinc fermentation products was tested through human patch testing.In vitro SZ95 cell model was used to study the oil-control efficacy of yeast/zinc fermentation products.The method of qRT-PCR was used to verify the expression of oil-secretion-related genes SREBP-1c,PPARG,and PI3K.Spectrophotometry was used to test the effect of yeast/zinc fermentation products on 5α-reductase.The oil-control effect of yeast/zinc fermentation products on scalp and the maintenance effect on hair follicles were studied through human efficacy testing and in vitro hair follicle model,respectively.The results showed that the yeast/zinc fermentation products at a content of 5%was safe and harmless to human health;the yeast/zinc fermentation products with a content of 0.8%-1.5%could significantly inhibit the activity of 5α-reductase.The yeast/zinc fermentation products at a content of 0.5%-2.0%could significantly inhibit the secretion of oil in SZ95 cells in vitro,and significantly downregulate the expression of oil-secretion-related genes SREBP-1c and PPARG.The yeast/zinc fermentation products at content of 1.0%and 2.0%could significantly inhibit the expression of PI3K.The yeast/zinc fermentation products at a content of 5%could significantly reduce scalp oil secretion,improve hair follicle cycle,and promote hair shaft growth.Therefore,the yeast/zinc fermentation products had certain scalp care effects and had positive effects in controlling oil,improving hair follicle health,and promoting hair shaft growth.关键词
酵母菌/锌发酵产物/控油/去屑/功效评价Key words
yeast/zinc fermentation product/oil control/anti-dandruff/efficacy evaluation分类
化学化工引用本文复制引用
尤孝鹏,彭宁,陈智仙..酵母菌/锌发酵产物在头皮护理中的功效研究[J].日用化学工业（中英文）,2024,54(9):1099-1105,7.
