酵母菌/锌发酵产物在头皮护理中的功效研究OA北大核心CSTPCD

The efficacy of yeast/zinc fermentation products in scalp care were studied from the aspects of safety,oil control and dandruff removal,and hair follicle maintenance.The safety of yeast/zinc fermentation products was tested through human patch testing.In vitro SZ95 cell model was used to study the oil-control efficacy of yeast/zinc fermentation products.The method of qRT-PCR was used to verify the expression of oil-secretion-related genes SREBP-1c,PPARG,and PI3K.Spectrophotometry was used to test the effect of yeast/zinc fermentation products on 5α-reductase.The oil-control effect of yeast/zinc fermentation products on scalp and the maintenance effect on hair follicles were studied through human efficacy testing and in vitro hair follicle model,respectively.The results showed that the yeast/zinc fermentation products at a content of 5%was safe and harmless to human health;the yeast/zinc fermentation products with a content of 0.8%-1.5%could significantly inhibit the activity of 5α-reductase.The yeast/zinc fermentation products at a content of 0.5%-2.0%could significantly inhibit the secretion of oil in SZ95 cells in vitro,and significantly downregulate the expression of oil-secretion-related genes SREBP-1c and PPARG.The yeast/zinc fermentation products at content of 1.0%and 2.0%could significantly inhibit the expression of PI3K.The yeast/zinc fermentation products at a content of 5%could significantly reduce scalp oil secretion,improve hair follicle cycle,and promote hair shaft growth.Therefore,the yeast/zinc fermentation products had certain scalp care effects and had positive effects in controlling oil,improving hair follicle health,and promoting hair shaft growth.