日用化学工业（中英文）2024，Vol.54Issue(9)：1133-1139,7.DOI:10.3969/j.issn.2097-2806.2024.09.015
激光共聚焦拉曼光谱法测定防晒剂经皮渗透作用及其应用研究
Determination of transdermal permeation of sunscreen by confocal Raman spectroscopy and its application
摘要
Abstract
Based on laser confocal Raman spectroscopy technology,a real-time in vivo testing method for the depth distribution and transdermal penetration of sunscreen in the stratum corneum of the skin was established using a skin component analyzer combined with multivariate linear regression analysis.Using volunteers'arms as the experimental subject,the consistency of transdermal penetration ability of three common sunscreen agents,OMC,DBHB,and EHT,was tested and analyzed in different skin regions of the arm.And the transdermal penetration of the sunscreen agents in sunscreen lotions with different formulation was compared.The results indicate that the relative standard deviation of the skin penetration of sunscreen in different areas on the inner side of the arm is less than 15%,indicating that the method is suitable for comparison of the skin penetration of different sunscreen products.After one hour of skin penetration,it is found that the transdermal penetration of the three sunscreen agents in the skin is reduced by about 60%,and the penetration depth of EHT is relatively shallow,when the in oil-in-water sunscreen compared to the nano emulsion sunscreen.This method has been effectively applied in the study of transdermal penetration of sunscreen agents,and can provide methodological references for transdermal absorption of cosmetics.关键词
拉曼光谱/在体/防晒剂/经皮渗透Key words
Raman spectra/in vivo/sunscreen/transdermal penetration分类
化学化工引用本文复制引用
谢宇,张少峰,杨武成,谢嘉颖,范瑞芳,谭建华..激光共聚焦拉曼光谱法测定防晒剂经皮渗透作用及其应用研究[J].日用化学工业（中英文）,2024,54(9):1133-1139,7.基金项目
广东省药品监督管理局科技创新项目(S2021TDZ140) （S2021TDZ140）
广州市科技计划项目(2023B04J0407) （2023B04J0407）
