神经病学与神经康复学杂志2024，Vol.20Issue(2)：58-66,9.DOI:10.12022/jnnr.2024-0063
神经退行性疾病与错误折叠异常聚集的蛋白质以及睡眠障碍
Neurodegenerative diseases associated with misfolding abnormal aggregates of proteins and sleep disorder
摘要
Abstract
Misfolding and clumping of proteins in the brain has been linked to various neurodegenerative diseases,these include Alzheimer's disease(AD),Parkinson's disease(PD)and amyotrophic lateral sclerosis(ALS).In pathological,these neurodegenerative diseases are related to protein misfolding and aggregation.AD is pathologically characterized by abnormal aggregation of β-amyloid protein and tau protein neurofibrillary tangles in the brain,and PD is pathologically related to abnormal aggregation of α-synuclein in dopaminergic neurons in the brain.The misfolding of specific protein,such as transactive response element DNA binding protein-43(TDP-43)and inclusion body formation,is one of the markers of ALS.Sleep disorder is not only a concomitant symptom of patients with these diseases,but also a precursor symptom of the onset of these diseases.This review elaborates on the abnormal protein aggregation characteristics and sleep disorder features of AD,PD,and ALS,and summarizes the potential of sleep disorder in early diagnosis and treatment of these diseases.Sleep disorder may become early diagnostic clues and treatment entry point for neurodegenerative diseases.关键词
神经退行性疾病/睡眠障碍/β-淀粉样蛋白/Tau蛋白神经原纤维缠结/α-突触核蛋白/反式激活应答DNA结合蛋白43Key words
Neurodegenerative diseases/Sleep disorder/β-Amyloid protein/Tau protein neurofibrillary tangles/α-Synuclein/Transactive response element DNA binding protein-43引用本文复制引用
荆玮,SAEREETAVEEKUN Natkitta,VORATUNYAKIT Napattharin,张海涵,李睿,韩小敬,潘卫东..神经退行性疾病与错误折叠异常聚集的蛋白质以及睡眠障碍[J].神经病学与神经康复学杂志,2024,20(2):58-66,9.基金项目
上海市浦东新区卫生健康委员会卫生行业专项(PW2022E-03) （PW2022E-03）
上海市中西医结合学会科研基金(shcim202201-4)Shanghai Pudong New Area Health Commission Industry Special Project(PW2022E-03) （shcim202201-4）
Research fund of Shanghai Association of Integrative Traditional Chinese and Western Medicine(shcim202201-4) （shcim202201-4）
