神经病学与神经康复学杂志2024，Vol.20Issue(2)：72-76,5.DOI:10.12022/jnnr.2024-0171
血浆置换治疗抗GAD抗体相关神经系统综合征一例报道
Plasma exchange therapy in neurological syndromes associated with anti-GAD antibodies:a case report
耿介立 1曹雯炜 1周夏俊 1王亦舒 1蒋仙国 1张瑛1
作者信息
- 1. 上海交通大学医学院附属仁济医院神经内科,上海 200127
- 折叠
摘要
Abstract
Objective:Enhance understanding of neuroautoimmune disorders associated with glutamic acid decarboxylase(GAD)antibodies to prevent misdiagnoses.
Methods:The clinical data of a patient primarily exhibiting stiff person syndrome was reported,reviewing symptomatology,pathogenesis,diagnostic processes,and treatment modalities based on existing literature.
Results:Symptoms in patients with GAD antibody-associated neurological syndrome vary and imaging results are often non-specific.The presence of GAD antibodies is crucial for accurate diagnosis.In this reported case,the patient showed improvement following plasma exchange therapy and maintained symptom stability with ongoing immunotherapy.
Conclusion:Stiff person syndrome frequently manifests in anti-GAD antibody associated neurological syndromes.The intrathecal synthesis of GAD antibodies strongly supports diagnosis.Immunomodulatory therapy has proven effective in treating this condition.关键词
谷氨酸脱羧酶抗体/僵人综合征/血浆置换Key words
Glutamic acid decarboxylase antibody/Stiff person syndrome/Plasma exchange引用本文复制引用
耿介立,曹雯炜,周夏俊,王亦舒,蒋仙国,张瑛..血浆置换治疗抗GAD抗体相关神经系统综合征一例报道[J].神经病学与神经康复学杂志,2024,20(2):72-76,5.
