miR-92b-5p对高糖诱导的足细胞凋亡的影响及其机制OACSTPCD
Effect of miR-92b-5p on podocyte apoptosis induced by hyperglycemia and its mechanism
目的 探讨miR-92b-5p在高糖诱导的足细胞损伤或凋亡过程中可能发挥的作用,并揭示其对线粒体功能的作用机制.方法 ①体外培养足细胞,分为对照组(NG组)和高糖组(HG组),通过高通量测序技术筛选差异表达的miRNA.②为了观察miR-92b-5p对足细胞线粒体功能和足细胞凋亡的影响,将正常血糖条件下培养的足细胞分为NC mimics、miR-92b-5p mimics、NC inhibitor、miR-92b-5p inhibitor组.为了…查看全部>>
Objective To investigate the possible role of miR-92b-5p in podocyte injury or apoptosis induced by hyperglycemia,and explore its effect on mitochondrial function and its molecular mechanism.Methods ① The podocytes were cultured and divided into normal glucose(NG)group and high glucose(HG)group,and the differentially expressed miRNAs were screened using high-throughput RNA-sequencing(RNA-seq)technology.②In order to investigate the effect of miR-92b-5p on pod…查看全部>>
闪玥;李文贤;陈彦霞;王婷;贺银习
河北医科大学第二医院内分泌科,石家庄 050000河北医科大学第二医院内分泌科,石家庄 050000||张家口市第一医院内分泌科河北医科大学第二医院内分泌科,石家庄 050000河北医科大学第二医院内分泌科,石家庄 050000石家庄市第三医院创伤二科
临床医学
miR-92b-5p微小RNA糖尿病糖尿病肾病足细胞凋亡线粒体功能障碍
miR-92b-5pmicroRNAsdiabetesdiabetic nephropathypodocyte apoptosismitochondrial dysfunction
《山西医科大学学报》 2024 (8)
985-993,9
河北省自然科学基金青年科学基金项目(H2020206108)河北省医学科学研究课题(20210151)
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