临床医学工程2024，Vol.31Issue(9)：1091-1092,2.DOI:10.3969/j.issn.1674-4659.2024.09.1091
益生菌补剂联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病患者的临床研究
Clinical Study on Probiotics Supplement Combined with Polyene Phosphatidylcholine in the Treatment of Patients with Nonalcoholic Fatty Liver Disease
李爱英 1朱桂应 2蒋彪 1陈琳琳1
作者信息
- 1. 遂宁市中心医院消化内科,四川遂宁 629000
- 2. 南充市中心医院心脏大血管外科,四川南充 637003
- 折叠
摘要
Abstract
Objective To explore the clinical effect of probiotics supplement combined with polyene phosphatidylcholine in the treatment of patients with nonalcoholic fatty liver disease(NAFLD).Methods 96 NAFLD patients from January 2021 to January 2023 were randomly divided into two groups,with 48 cases in each group.The control group was treated with polyene phosphatidylcholine,and the observation group was treated with probiotics supplement combined with polyene phosphatidylcholine.The intestinal flora,oxidative stress indicators(SOD,MDA)and adverse reactions were compared between the two groups.Results After 8 weeks of treatment,the number of bifidobacteria and lactobacilli in the observation group was higher than that in the control group,and the number of enterobacteria and enterococcus was lower than that in the control group(P＜0.05).After 8 weeks of treatment,the serum SOD level of the observation group was lower than that of the control group,and the MDA level was higher than that of the control group(P＜0.05).During the treatment,no obvious adverse drug reactions was found in the two groups.Conclusions Probiotics supplement combined with polyene phosphatidylcholine in the treatment of NAFLD patients can significantly improve the intestinal flora status and oxidative stress injury,which is safe and reliable.关键词
益生菌补剂/多烯磷脂酰胆碱/非酒精性脂肪性肝病/肠道菌群/氧化应激Key words
Probiotics supplement/Polyene phosphatidylcholine/Nonalcoholic fatty liver disease/Intestinal flora/Oxidative stress分类
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李爱英,朱桂应,蒋彪,陈琳琳..益生菌补剂联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病患者的临床研究[J].临床医学工程,2024,31(9):1091-1092,2.
