中国康复2024，Vol.1Issue(10)：599-603,5.DOI:10.3870/zgkf.2024.10.005
听觉统合训练联合重复经颅磁刺激对孤独症谱系障碍患儿疗效的观察
Effects of auditory integration training combined with repetitive transcranial magnetic stimulation on behavioral symp-toms in children with autism spectrum disorder
摘要
Abstract
Objective:To explore the effect of auditory integration training(AIT)combined with repetitive tran-scranial magnetic stimulation(rTMS)on behavioral symptoms in children with autism spectrum disorder(ASD).Methods:This study was conducted on 98 children with ASD admitted to our hospital from July 2022 to December 2023.In this study,1 case was excluded and 1 case was dislodged from the control group;2 cases were excluded and 1 case was dislodged from the study group,resulting in the inclusion of 93 children with ASD.The children were randomly divided into 2 groups,47 in the control group and 46 in the study group.The control group received conventional rehabilitation training and rTMS treatment,while the study group was given AIT on the basis of the control group,using the autism behavioral rating scale(ABC)and the psychoeducational scale for children with ASD,3rd edition(PEP-3),and the event-related potentials(ERPs)and the brain-derived neurotrophic factor(BD-NF)test were observed.Behavioral symptoms,functional and behavioral status,ERP and BDNF levels were com-pared between the 2 groups before and after 12 weeks of intervention.Results:After 12 weeks of intervention,the scores of 5 items in ABC in both groups were lower than before intervention(P＜0.01),and 5 scores in the study group were lower than in the rTMS group(P＜0.01).After 12 weeks of intervention,the scores of two items in PEP-3,P300 amplitude,and serum level of BDNF in the two groups were higher than before intervention(P＜0.05),and those in the study group were higher than in the rTMS group(P＜0.01).After 12 weeks of interven-tion,the P300 latency in both groups were shorter than before intervention(P＜0.01,0.05),and the incubation pe-riod of P300 in the study group was shorter than in the rTMS group(P＜0.01).Conclusion:AIT combined with rTMS can obviously increase serum BDNF level,effectively regulate P300 potential,and obviously improve behav-ioral symptoms,function,and behavioral status in children with ASD.关键词
听觉统合训练/重复经颅磁刺激/孤独症谱系障碍/行为学症状Key words
auditory integration training/repetitive transcranial magnetic stimulation/autism spectrum dis-order/behavioral symptoms分类
医药卫生引用本文复制引用
左晓晓,杜宝媛,王阔,冉欣,李健..听觉统合训练联合重复经颅磁刺激对孤独症谱系障碍患儿疗效的观察[J].中国康复,2024,1(10):599-603,5.基金项目
广东省医学科学技术研究基金项目(B2024005) （B2024005）
