中国临床药理学杂志2024，Vol.40Issue(17)：2479-2482,4.DOI:10.13699/j.cnki.1001-6821.2024.17.005
肺炎患者伴发静脉血栓栓塞症的影响因素研究
Study on influencing factors of venous thromboembolism in pneumonia patients
摘要
Abstract
Objective To analyze the incidence of venous thromboembolism(VTE)in pulmonary patients and explore the assessment and prevention of the risk of pneumonia accompanied VTE.Methods The patients with pneumonia were divided into control group(simple pneumonia)and treatment group(with VTE)according to the condition of VTE.Demographic data,blood routine,coagulation index,liver and kidney function index and blood gas index were collected.Statistical methods like chi square test,t-test and nonparametric rank sum test were applied to compare the differences between the two groups.Finally,the nomogram was established according to the logistic regression results and the receiver operating characteristic(ROC)curve was calculated.Results 106 cases in control group and 29 cases in treatment group.Univariate analysis showed that age,D-dimer,fibrinogen degradation products,white blood cell count,neutrophil count,albumin-globulin ratio were statistically significant(P＜0.05).Multivariate logistic regression analysis suggests that age[odds ratio(OR)=1.052],D-dimer(OR=2.339),and albumin/globulin(OR=0.042)are independent affecting factors for VTE in pneumonia patients.A nomogram was developed and ROC was calculated,the area under curve(AUC)was 0.754.Conclusion High age,elevated D-dimer and decreased albumin/globulin are independent risk factors for VTE in pneumonia patients.More over,the established prediction model has good accuracy.关键词
肺炎/静脉血栓栓塞症/相关性/诺模图Key words
pulmonary/venous thromboembolism/incidence/nomogram分类
医药卫生引用本文复制引用
李瑞娟,牛镜,贾鹏燕,张卓,阙呈立,向倩,崔一民..肺炎患者伴发静脉血栓栓塞症的影响因素研究[J].中国临床药理学杂志,2024,40(17):2479-2482,4.基金项目
国家自然科学基金面上基金资助项目(82274024) （82274024）
