中国临床药理学杂志2024，Vol.40Issue(17)：2575-2579,5.DOI:10.13699/j.cnki.1001-6821.2024.17.025
布拉氏酵母菌治疗儿童腹泻的有效性和安全性分析
Analysis of the efficacy and safety of Saccharomyces boulardii in the treatment of pediatric diarrhea
摘要
Abstract
Objective To compare the efficacy and safety of Saccharomyces boulardii and other probiotics in the treatment of pediatric diarrhea.Methods Retrieved from PubMed,Embase,CBM,Wanfang data,CNKI and VIP,randomized controlled trial(RCTs)about Saccharomyces boulardii(treatment group)vs other probiotics(control group)were collected.After screening the literature,extracting data and evaluating the quality,Meta-analysis was performed by using RevMan 5.3 and Stata 17.0 software.Results A total of 30 RCTs were included,involving 3 082 children.Results of Meta-analysis showed there was no statistical significance in the duration of diarrhea[mean difference(MD)=-0.65,95％confidence interval(CI)=-1.44-0.14,P＞0.05]or the total incidence of adverse reactions[odds ratio(OR)=0.85,95％CI=0.44-1.62,P＞0.05].The total effective rate(OR=1.60,95％CI=1.08-2.36,P＜0.05)and the number of stools(MD=-0.66,95％CI=-1.00--0.32,P＜0.01)in the treatment group were significantly better than control group.There was statistically significant difference in the duration of diarrhea between the two groups treated with diarrhea with fever(MD=1.81,95％CI=1.12-2.49,P＜0.01)and rotavirus gastroenteritis(MD=-0.92,95％CI=-1.20--0.64,P＜0.01).In the treatment of diarrhea with fever,the duration of diarrhea in the control group was significantly shorter than that in the treatment group.The duration of diarrhea in the treatment group was significantly shorter than that control group.At the same time,the duration of diarrhea in children with diarrhea treated with treatment group was significantly shorter than that of control group Bifidobacterium tetragenous viable(MD=-0.84,95％CI=-1.09--0.58,P＜0.01)and control group combined Bacillus subtilis and Enterococcus faecium enteric-coated(MD=-1.35,95％CI=-2.30-0.39,P＜0.01).Conclusion The safety of Saccharomyces boulardii are similar to other probiotics.The efficacy and the number of stools with Saccharomyces boulardii are significantly better than other probiotics in the treatment of diarrhea.The duration of diarrhea in Saccharomyces boulardii group was significantly shorter than other probiotics,while in the treatment of antibiotic-associated diarrhea,the duration of diarrhea of Saccharomyces boulardii was the same as that of other probiotics.However,the duration of diarrhea in children with diarrhea treated with Saccharomyces boulardii was significantly longer than other probiotics.关键词
布拉氏酵母菌/枯草杆菌二联活菌/双歧杆菌三联活菌/双歧杆菌四联活菌/儿童腹泻/Meta分析Key words
Saccharomyces boulardii/combined Bacillus subtilis and Enterococcus faecium enteric-coated/Bifidobacterium triple live bacteria/Bifidobacterium tetragenous viable/pediatric diarrhea/Meta-analysis分类
药学引用本文复制引用
牟丽莉,张潇丹,刘璐,陈春红,陈卓,尹慧,闫美兴..布拉氏酵母菌治疗儿童腹泻的有效性和安全性分析[J].中国临床药理学杂志,2024,40(17):2575-2579,5.基金项目
山东省药学会科研基金资助项目(SDSYXH-KY-202208) （SDSYXH-KY-202208）
