中国临床药理学杂志2024，Vol.40Issue(17)：2596-2600,5.DOI:10.13699/j.cnki.1001-6821.2024.17.029
中药调控AGE-RAGE信号通路治疗多囊卵巢综合征的研究现状
Research progress of Chinese medicine regulating AGE-RAGE signaling pathway in the treatment of polycystic ovary syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disease in gynecology.The main clinical manifestations are infertility,hirsuty,obesity,menstrual disorders,etc.,which seriously affect women's health.Studies have shown that the mechanism of action of traditional Chinese medicine in the treatment of PCOS involves a variety of signaling pathways,among which advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway is an important pathway regulating inflammation and oxidative stress.More and more Chinese herbal compounds,single herbs and their extracts can reduce inflammation,oxidative stress,insulin resistance and hyperandrogenemia in patients by regulating AGE-RAGE signaling pathway,which provides a new strategy and direction for the treatment of PCOS.However,there is currently no comprehensive summary of Chinese medicine intervention in the treatment of PCOS by AGE-RAGE signaling pathway.Therefore,this paper reviews the current research status of Chinese medicine regulation of AGE-RAGE signaling pathway in the treatment of PCOS in recent years,so as to provide new directions and thoughts for further research on PCOS.关键词
中药/多囊卵巢综合征/晚期糖基化终产物-晚期糖基化终末产物受体信号通路/治疗Key words
traditional Chinese medicine/polycystic ovary syndrome/advanced glycation end products-receptor for advanced glycation end products signaling pathway/treatment分类
医药卫生引用本文复制引用
冉冰清,黄进格,吴月娟,王芳..中药调控AGE-RAGE信号通路治疗多囊卵巢综合征的研究现状[J].中国临床药理学杂志,2024,40(17):2596-2600,5.基金项目
兰州大学第二医院"萃英科技创新"基金资助项目(CY2022-MSB03) （CY2022-MSB03）
