中国脑血管病杂志2024，Vol.21Issue(8)：552-558,7.DOI:10.3969/j.issn.1672-5921.2024.08.007
环腺苷酸激活交换蛋白1/RAS相关蛋白1信号通路在脑缺血-再灌注损伤发病机制中的研究进展
Research progress of cyclic AMP-activated exchange protein 1/RAS-related protein 1 signal pathway in the pathogenesis of cerebral ischemia-reperfusion injury
摘要
Abstract
Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.关键词
脑缺血再灌注损伤/Epac1/Rap1信号通路/发病机制/综述Key words
Cerebral ischemia-reperfusion injury/Epac1/Rap1 signaling pathway/Pathogenesis/Review引用本文复制引用
吕雪,孙毅红,华志鹏,贾建新..环腺苷酸激活交换蛋白1/RAS相关蛋白1信号通路在脑缺血-再灌注损伤发病机制中的研究进展[J].中国脑血管病杂志,2024,21(8):552-558,7.基金项目
国家自然科学基金(81860215) （81860215）
内蒙古自治区自然科学基金(2021MS08010) （2021MS08010）
