环腺苷酸激活交换蛋白1/RAS相关蛋白1信号通路在脑缺血-再灌注损伤发病机制中的研究进展OA北大核心CSTPCD
Research progress of cyclic AMP-activated exchange protein 1/RAS-related protein 1 signal pathway in the pathogenesis of cerebral ischemia-reperfusion injury
脑缺血-再灌注损伤(CIRI)是缺血性卒中患者恢复患侧脑组织血流时引发的严重并发症.CIRI患者常伴有神经功能减退、认知障碍、情绪障碍等,对日常生活产生严重影响.目前CIRI易被早期诊断,但相关特异性治疗方法相对较少.作者对环腺苷酸激活交换蛋白1/RAS相关蛋白1(Epac1/Rap1)信号通路与CIRI的相关性研究进行综述,以期为CIRI患者的临床治疗提供新思路.
Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.
吕雪;孙毅红;华志鹏;贾建新
014010 内蒙古科技大学包头医学院研究生院
脑缺血再灌注损伤Epac1/Rap1信号通路发病机制综述
Cerebral ischemia-reperfusion injuryEpac1/Rap1 signaling pathwayPathogenesisReview
《中国脑血管病杂志》 2024 (008)
552-558 / 7
国家自然科学基金(81860215);内蒙古自治区自然科学基金(2021MS08010)
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