基于病理生理学的儿童脓毒性休克的救治OA北大核心CSTPCD

Sepsis is a dysregulated host response to infection leading to life-threatening organ dysfunction with a complex pathophysiology that involves major mechanisms including immune imbalance,microcirculatory disorders,and mitochondrial dysfunction.Septic shock,a combination of sepsis with cardiovascular dysfunction,is one of the etiologic factors contributing to high mortality in critically ill children.This article summarizes the key points of treatment of septic shock in children based on pathophysiology,including infection control,immunomodulation,and improvement of microcirculation and mitochondrial function,which will help clinicians understand the treatment of septic shock in children.