中国实用儿科杂志2024，Vol.39Issue(9)：669-673,5.DOI:10.19538/j.ek2024090605
基于病理生理学的儿童脓毒性休克的救治
Treatment for children with septic shock based on pathophysiology
摘要
Abstract
Sepsis is a dysregulated host response to infection leading to life-threatening organ dysfunction with a complex pathophysiology that involves major mechanisms including immune imbalance,microcirculatory disorders,and mitochondrial dysfunction.Septic shock,a combination of sepsis with cardiovascular dysfunction,is one of the etiologic factors contributing to high mortality in critically ill children.This article summarizes the key points of treatment of septic shock in children based on pathophysiology,including infection control,immunomodulation,and improvement of microcirculation and mitochondrial function,which will help clinicians understand the treatment of septic shock in children.关键词
脓毒性休克/感染/免疫/微循环/线粒体Key words
septic shock/infection/immune/microcirculation/mitochondria分类
医药卫生引用本文复制引用
应佳云,陆国平..基于病理生理学的儿童脓毒性休克的救治[J].中国实用儿科杂志,2024,39(9):669-673,5.基金项目
国家重点研发计划(2021YFC2701800,2021YFC2701802,2021YFC2701805) （2021YFC2701800,2021YFC2701802,2021YFC2701805）
上海市卫生健康系统重点扶持学科项目(2023ZDFC0103) （2023ZDFC0103）
