中国实用外科杂志2024，Vol.44Issue(8)：916-921,6.DOI:10.19538/j.cjps.issn1005-2208.2024.08.16
多学科综合治疗协作组模式对行手术治疗腹膜后脂肪肉瘤病人预后的影响:一项倾向性评分匹配的回顾性队列研究
Effects of the multidisciplinary team on the prognosis of patients undergoing surgical treatment for retroperitoneal liposarcoma:a propensity score-matched retrospective cohort study
摘要
Abstract
Objective To investigate the effect of a multidisciplinary team(MDT)model on the prognosis of patients with retroperitoneal liposarcoma(RLPS).Methods The clinical and pathological data of patients with RLPS treated at the Department of Retroperitoneal Tumor and Soft Tissue Sarcoma Surgery of Zhongshan Hospital,Fudan University from January 2009 to December 2022 were retrospectively analyzed.210 patients participated in MDT discussions,and 375 patients did not.The two groups of patients were matched 1:1 by propensity score matching(PSM),and 208 cases were selected in the MDT group and the non-MDT group,respectively.The clinical data of the two groups were analyzed and compared.Results After PSM matching,there were no statistically significant differences in gender,age,tumor length,tumor number,tumor origin,or recurrence between the two groups(P＞0.05).The results of the multivariate Cox analysis after PSM showed that recurrent tumor,FNCLCC grade Ⅲ,and surgical R2 margin status were independent risk factors for overall survival(OS).Recurrent tumor,multiple lesions,FNCLCC grade Ⅲ,and surgical R2 margin status were independent risk factors for progression-free survival(PFS).Whether to participate in MDT was the independent protective factor for PFS(HR=0.663,95％CI 0.515-0.855,P=0.002)and OS(HR=0.614,95％CI 0.414-0.911,P=0.015).The OS rates at 1,3,and 5 years were 93.6％,78.9％,and 71.6％in the MDT group,and 91.7％,67.2％,and 60.7％in the non-MDT group,respectively.The PFS rates at 1,3,and 5 years were 78.2％,49.8％,and 35.5％in the MDT group,and 68.4％,38.9％,and 29.8％in the non-MDT group,respectively.The OS rate(P=0.017)and PFS rate(P=0.003)in the MDT group were higher than those in the non-MDT group.Conclusion MDT model may improve the outcomes of patients undergoing surgical treatment for RLPS,but the specific benefits may require individualized assessments.关键词
腹膜后脂肪肉瘤/多学科综合治疗协作组/总生存期/无进展生存期Key words
retroperitoneal liposarcoma/multidisciplinary team/overall survival/progression-free survival分类
医药卫生引用本文复制引用
朱涛,童汉兴,张勇,周宇红,陆维祺,姜铨,王炯元,丁玉芹,王斌梁,杨珏,王毅超,张立,侯英勇..多学科综合治疗协作组模式对行手术治疗腹膜后脂肪肉瘤病人预后的影响:一项倾向性评分匹配的回顾性队列研究[J].中国实用外科杂志,2024,44(8):916-921,6.基金项目
福建省自然科学基金面上项目(No.2023J01698) （No.2023J01698）
厦门市自然科学基金面上项目(No.3502Z20227279) （No.3502Z20227279）
