中国畜牧杂志2024，Vol.60Issue(9)：71-78,8.DOI:10.19556/j.0258-7033.20231005-02
染色质三维构象在精子发生中的研究进展
Research Progress on Three-dimensional Chromatin Conformation in Spermatogenesis
摘要
Abstract
Chromatin plays a vital role in the transmission of genetic information across generations and serves as a critical medium for the precise regulation of gene and protein expression within cells.The study of chromatin structure has been significantly enhanced by the continuous progress in scientific technology,particularly through high-throughput chromatin conformation capture(High-through chromosome conformation capture,Hi-C)technology,especially there is a clear understanding of chromatin compartments,chromatin territories,etc.Throughout the process of spermatogenesis,there is a significant alteration in the chromatin structure,which is of great significance for the regulation of gene expression.Spermatogenesis is a complicated process that includes spermatogonia differentiation,spermatocytes meiosis,spermatids spermiogenesis and final release of spermatozoa.This review primarily focuses on the three-dimensional chromatin conformation capture technology and its associated methodologies,the hierarchical organization of chromatin,and the progress of 3D conformational changes of chromatin during spermatogenesis,providing new ideas for studying the mechanism of spermatogenesis.关键词
精子发生/染色质构象捕获/三维基因组学Key words
Spermatogenesis/Chromatin conformational capture/3D genomics分类
农业科技引用本文复制引用
金昊延,李颀菡,马媛,王娜娜,胡亚美,马云,张令锴..染色质三维构象在精子发生中的研究进展[J].中国畜牧杂志,2024,60(9):71-78,8.基金项目
宁夏大学博士科研启动经费(030700002306) （030700002306）
宁夏回族自治区重点研发(2023BCF01006) （2023BCF01006）
