结直肠肛门外科2024，Vol.30Issue(4)：510-514,5.DOI:10.19668/j.cnki.issn1674-0491.2024.04.022
肌卫星细胞对神经源性大便失禁肛门括约肌修复影响的研究现状
Research progress on the effect of muscle satellite cells on anal sphincter repair in neuro-genic fecal incontinence
摘要
Abstract
Neurogenic fecal incontinence refers to the dysfunction of anal sphincter contraction caused by degenerative at-rophy of the anal sphincter secondary to pudendal nerve injury,manifested as involuntary leakage of feces from the anus.Muscle satellite cells are a group of adult stem cells in skeletal muscle that can be activated and differentiate into stem cells and myoblasts after skeletal muscle injury,reconstructing muscle fibers.The process of atrophy of the external anal sphincter is intimately linked to the number and activation-differentiation level of muscle satellite cells,and the acti-vation and proliferation of muscle satellite cells play a pivotal role in the injury and regeneration of the anal sphincter.This process is regulated by the ecological niche and signal transduction of various cells and cytokines,serving as an im-portant target for the treatment of neurogenic fecal incontinence.This article reviews the research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence.关键词
神经源性大便失禁/肌卫星细胞/退化性萎缩/括约肌再生Key words
neurogenic fecal incontinence/muscle satellite cells/degenerative atrophy/sphincter regeneration分类
医药卫生引用本文复制引用
何津超,王群博,秦钦,赵玲,董青军..肌卫星细胞对神经源性大便失禁肛门括约肌修复影响的研究现状[J].结直肠肛门外科,2024,30(4):510-514,5.基金项目
国家自然科学基金面上项目(82074441) （82074441）
上海市临床重点专科(shslczdzk04301) （shslczdzk04301）
