分析化学2024，Vol.52Issue(9)：1234-1243,10.DOI:10.19756/j.issn.0253-3820.241277
甲状腺球蛋白检测技术的研究进展
Recent Progress in Detection Techniques of Thyroglobulin
摘要
Abstract
Thyroglobulin(Tg)is a glycoprotein with large molecular weight,which is synthesized and secreted into the bloodstream by thyroid follicular cells.The concentration level of Tg in blood is one of the important biomarkers for diagnosis of thyroid diseases such as differentiated thyroid cancer(DTC),subacute thyroiditis,etc..Radioimmunoassay(RIA),immunoradiometric assay(IRMA),and immunochemiluminescence assay(ICMA)are the main clinical methods for detecting Tg.Recently,for meeting the requirement of detecting low concentration of Tg in blood after thyroid clearance surgery,researchers have developed various high-performance analysis methods for detecting Tg concentration in blood samples,providing new assays for thyroid disease screening and efficacy evaluation.This review summarized the analysis methods of Tg,especially the new progresses in the biosensors for monitoring low concentration of Tg in blood during the past five years.The current technical challenges of these methods in clinical applications were briefly discussed,which might provide useful information for developing new liquid biopsy methods of DTC.关键词
甲状腺球蛋白/生物传感器/甲状腺疾病/液体活检/评述Key words
Thyroglobulin/Biosensors/Thyroid disease/Liquid biopsy/Review引用本文复制引用
吴越,单勇杰,曹守纪,季世琦,陈渤文,孟宪瑛,王振新..甲状腺球蛋白检测技术的研究进展[J].分析化学,2024,52(9):1234-1243,10.基金项目
吉林省自然科学基金-国家重点实验室(学科类)重大专项项目(No.SKL202302030)资助. Supported by the Natural Science Foundation of Jilin Province-Key Special Project of National Key Laboratory(No.SKL202302030). （学科类）
