肝胆胰外科杂志2024，Vol.36Issue(9)：552-557,6.DOI:10.11952/j.issn.1007-1954.2024.09.008
早期肿瘤退缩与白蛋白紫杉醇联合吉西他滨一线治疗晚期胰腺癌效果及预后的关系
Relationship of efficacy and prognosis between early tumor shrinkage and albumin paclitaxel combined with gemcitabine in the first-line treatment of advanced pancreatic cancer
彭登付 1尚官敏 1董良 1童国琦1
作者信息
- 1. 绍兴市中心医院 肿瘤内科,浙江 绍兴 312030
- 折叠
摘要
Abstract
Objective To explore the relationship of efficacy and prognosis between early tumor shrinkage(ETS)and albumin paclitaxel combined with gemcitabine(AG regimen)in the first-line treatment of advanced pancreatic cancer.Methods A retrospective analysis was conducted on 38 advanced pancreatic cancer patients in Shaoxing Central Hospital from Jan.2018 to Jan.2023.The optimum critical value of ETS was analyzed by receiver operating characteristic(ROC)curve.Survival analysis was conducted by Kaplan-Meier method and Log-rank test,and the relationship between ETS and the prognosis of advanced pancreatic cancer was analyzed by Cox regression.Results For the 38 advanced pacreatic patients,the median progression-free survival(PFS)was 6.20(95%CI 5.90-6.50)months,the median overall survival(OS)was 12.00(95%CI 9.74-14.27)months,the disease control rate(DCR)was 82.6%,and the best critical value of ETS was 9.25%.The patients with ETS≥9.25%(n=17)had longer PFS(8.00 months vs 4.80 months,P<0.05)and OS(16.50 months vs 10.20 months,P<0.05)than those with ETS<9.25%(n=21).Cox multivariate regression analysis showed that ETS was an independent factor affecting the survival and prognosis of advanced pancreatic cancer(PFS:HR=0.341,95%CI 0.135-0.680,P<0.05;OS:HR=0.225,95%CI 0.084-0.603,P<0.05).Conclusion The AG regimen is effective in the first-line treatment of advanced pancreatic cancer.ETS can effectively predict the efficacy and prognosis of advanced pancreatic cancer with AG regimen.关键词
早期肿瘤退缩/晚期胰腺癌/白蛋白紫杉醇/吉西他滨/预后Key words
early tumor shrinkage/advanced pancreatic cancer/albumin paclitaxel/gemcitabine/prognosis分类
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彭登付,尚官敏,董良,童国琦..早期肿瘤退缩与白蛋白紫杉醇联合吉西他滨一线治疗晚期胰腺癌效果及预后的关系[J].肝胆胰外科杂志,2024,36(9):552-557,6.
