SPATS2通过激活NOTCH信号通路促进喉鳞状细胞癌进展的机制研究OA北大核心CSTPCD
SPATS2 promotes LSCC process by activating the NOTCH signaling pathway
目的:探究丝氨酸精子发生相关蛋白2(spermatogenesis associated serine rich 2,SPATS2)影响喉 鳞 状 细 胞 癌(larynx squamous cell carcinoma,LSCC)增 殖、迁 移、侵 袭 和 上 皮 间 质 转 化(epithelial-mesenchymal transition,EMT)发生的分子机制,从而为寻找LSCC筛查、诊断和治疗的潜在靶点提供理论依据.方法:从TCGA…查看全部>>
Objective:This study aims to investigate the molecular mechanisms through which spermatogenesis associated ser-ine rich 2(SPATS2)influences larynx squamous cell carcinoma(LSCC)by affecting proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT).The findings will provide a theoretical basis for identifying potential targets for screen-ing,diagnosis,and treatment LSCC.Methods:Clinical and RNA-seq data for LSCC were obtained from the TCGA da…查看全部>>
张晓然;潘夏至;鲁钺皓;刘段莎丽;郑世康;王程;刘明波
山东第二医科大学临床医学院,山东 潍坊 261000山东第二医科大学临床医学院,山东 潍坊 261000山东第二医科大学临床医学院,山东 潍坊 261000山东第二医科大学临床医学院,山东 潍坊 261000解放军总医院海南医院耳鼻咽喉头颈外科,海南 三亚 572000解放军总医院海南医院耳鼻咽喉头颈外科,海南 三亚 572000解放军总医院海南医院耳鼻咽喉头颈外科,海南 三亚 572000
临床医学
喉鳞状细胞癌NOTCH信号通路SPATS2增殖转移上皮间质转化
Larynx squamous cell carcinomaNOTCH signaling pathwaySPATS2ProliferationMetastasisEMT
《海南医学院学报》 2024 (18)
1370-1380,11
This study was supported by Molecular Typing Related Research on Laryngeal Cancer(LCYX202105),Pathogenic Mechanism of Laryngeal Cancer Based on Single Cell Sequencing and Spatial Transcriptome Technology(LCYX202202),Key Technology Research and Application of Cancer Prevention and Treatment in Hainan Province(ZDKJ202005) 喉癌的分子分型相关研究(LCYX202105),基于单细胞测序与空间转录组技术的喉癌致病机理研究(LCYX202202),海南省肿瘤防治关键技术研究与应用(ZDKJ202005)
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