mPEG-PDLLA&mPEG-DSPE载奥沙利铂复合胶束的制备及性能评价OA北大核心CSTPCD
Preparation and performance evaluation of mPEG-PDLLA&mPEG-DSPE/OXA mixed micelles
目的:改善胶束存在的水溶性药物包封率低、胶束稳定性较差以及难入胞等问题.方法:采用瞬时纳米沉淀技术以mPEG-DSPE和mPEG-PDLLA为载体材料,奥沙利铂为模型药物,制备了mPEG-DSPE&mPEG-PDLLA/OXA复合胶束,并与载药普通胶束mPEG-PDLLA/OXA和载药双层脂质杂化纳米粒LPHNP/OXA进行对比.结果:采用单因素筛选得到复合NPs的最佳制备工艺为总流速4 mL/min、流速比1∶3、总材料浓度为3.75 …查看全部>>
Objective:To address the challenges associated with the low encapsulation efficiency of water-soluble drugs,poor stability and negligible endocytosis in micelles.Method:mPEG-DSPE and mPEG-PDLLA were used as carrier materials and ox-aliplatin as model drug to prepare mPEG-DSPE&mPEG-PDLLA/OXA mixed NPs by flash nanoprecipitation.The performances of mixed NPs were compared with mPEG-PDLLA/OXA NPs and LPHNP/OXA NPs.Results:The optimal preparation process of …查看全部>>
赵文豪;龚婷;熊迎新;霍美蓉
中国药科大学药学院,江苏 南京 210009||重庆药友制药有限公司,重庆 401121重庆药友制药有限公司,重庆 401121重庆药友制药有限公司,重庆 401121中国药科大学药学院,江苏 南京 210009
药学
胶束瞬时纳米沉淀奥沙利铂
MicellesOxaliplatinFNP
《海南医学院学报》 2024 (18)
1381-1391,11
Innovation Talents in Key Industries Program of Chongqing Talent Program,China(No.CQYC20220305379) "重庆英才计划"创新领域人才(重点产业领域)项目(CQYC20220305379)
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