泛素-蛋白酶体系统在溃疡性结肠炎中的研究进展OA北大核心CSTPCD

Ulcerative colitis(UC)is a chronic recurrent non-specific inflammatory bowel disease occurring in the intestinal mucosa.Currently,it is believed that its pathogenesis may be related to the intestinal epithelial barrier,intestinal microecology,and immune factors,and the effect of the clinical treatment is not ideal.The ubiquitin proteasome system(UPS)is the main path-way of protein degradation in the cell,which mainly degrades misfolded proteins to maintain cell homeostasis.Its abnormal func-tion can lead to dyshomeostasis of cells,which has an important effect on the occurrence and development of UC.This article re-views the relationship between ubiquitin,deubiquitin,ubiquitin ligase,and ubiquitin related to the preparations in UPS and the pathogenesis of UC,aiming to provide new ideas for the diagnosis and treatment of UC.