海南医学院学报2024，Vol.30Issue(18)：1433-1440,8.DOI:10.13210/j.cnki.jhmu.20240522.001
帕金森病神经炎症的发生与免疫调节疗法
Occurrence of neuroinflammation in Parkinson's disease and immunoregulatory therapy
摘要
Abstract
The pathological nature of Parkinson's disease is selective and progressive death of substantia nigra dopaminergic neurons,but the specific pathogenesis is unknown.Persistent neuroinflammation plays an important role in the pathogenesis of PD.The main pathological manifestations are activation of a large number of immune cells and release of inflammatory factors,and its neurotoxic effect will aggravate neuronal injury.Immunotherapy intervention can induce neuroprotective environment in the central nervous system,attenuate neuroinflammation,prevent further neurodegeneration of PD and slow down the disease progres-sion to improve clinical symptoms.This article reviews the manifestations and pathogenesis of neuroinflammation in PD,and pro-vides possible ideas for the prevention and treatment of PD from the perspective of neuroimmune regulation.关键词
帕金森病/神经炎症/免疫细胞/炎症因子/免疫调节疗法Key words
Parkinson's disease/Neuroinflammation/Immune cells/Inflammatory factors/Immunoregulatory therapy分类
医药卫生引用本文复制引用
周美,倪慧心,刘海鑫,张楚天,高正涛,范自立,王林,林瑶,许茜..帕金森病神经炎症的发生与免疫调节疗法[J].海南医学院学报,2024,30(18):1433-1440,8.基金项目
National Natural Science Foundation Youth Project(81904263),Fujian Province Traditional Chinese Medicine Science and Technology Program(2021zyjc02),Fujian University of Traditional Chinese Medicine Health Management Joint Provincial Clinical Key Specialty Construction Project(Geriatrics)(XJG2023018),Fujian University of Traditional Chinese Medicine Management Project Youth Project(X2023010) 国家自然科学基金青年项目(81904263) （81904263）
福建省中医药科技项目(2021zyjc02) （2021zyjc02）
福建中医药大学中医健康管理学联合省级临床重点专科建设项目(老年病科)(XJG2023018) （老年病科）
福建中医药大学校管课题青年项目(X2023010) （X2023010）
