华西口腔医学杂志2024，Vol.42Issue(5)：629-635,7.DOI:10.7518/hxkq.2024.2024133
骨管技术在Ⅱ期下颌骨药物相关性颌骨坏死手术中的应用初探
Application of bone perforation in the surgery of medication-related osteonecrosis of the jaw in stageⅡ
摘要
Abstract
Objective This study aimed to explore the effect of surgery combined with bone perforation for treating stage Ⅱ medication-related osteonecrosis of the jaw(MRONJ).Methods A total of 21 patients with stage Ⅱ mandibu-lar MRONJ who underwent surgical treatment from June 2020 to June 2023 were included in this study.Retrospective analysis was conducted on their clinical data,including gender,age,primary disease,drug name and administration meth-od,pre-surgery drug cessation,and prognosis.The cohort comprised 14 males and 7 females,with an average age at on-set of 68.33±10.74 years.According to the guidelines of the American Association of Oral and Maxillofacial Surgeons,the included patients had stage Ⅱ mandibular MRONJ.The treatment approach consisted of partial mandibulectomy combined with bone perforation techniques,ensuring tension-free suturing of soft tissues.Follow-up was performed reg-ularly,and the curative effect was evaluated.The SF-12 health survey was used to assess the quality of life for all pa-tients before and after surgery.Results A total of 21 patients were followed up for 8-38 months after surgery,and the mucosal healing of 17 patients was good(80.95%).The postoperative quality of life score(83.62±5.90)was sig-nificantly higher than that before operation(63.67±4.70,P<0.05).Conclusion Surgery combined with bone per-foration technique is an effective treatment method with high success rate in refractory stage Ⅱ MRONT patients.关键词
下颌骨/药物相关性颌骨坏死/手术治疗/颌骨部分切除术Key words
mandible/medication-related osteonecrosis of the jaw/surgical treatment/partial mandibulectomy分类
医药卫生引用本文复制引用
高娜,田美,孙亚威,王丹妮,孙国文..骨管技术在Ⅱ期下颌骨药物相关性颌骨坏死手术中的应用初探[J].华西口腔医学杂志,2024,42(5):629-635,7.基金项目
Nanjing Health Science and Technology Development Special Fund Project(YKK22183) 南京市卫生科技发展专项资金项目(YKK22183) （YKK22183）
