乳酸对孕早期小鼠胎盘促血管生成基因表达及胎鼠生长的影响OACSTPCD
Effects of lactic acid on expression of placental angiogenesis and fetal growth in mice during early pregnancy
背景 胚胎着床过程中,子宫内膜基质细胞发生蜕膜化,进一步支持妊娠.子宫内膜蜕膜化过程中存在Warburg样糖酵解,产生大量乳酸.目的 探讨乳酸对孕早期小鼠胎盘促血管生成基因表达及胎鼠生长的影响.方法 选择 6～8周龄的CD1雌性小鼠,与雄鼠交配成功后,随机分为抑制剂组和对照组,每组 12只.抑制剂组从小鼠孕 4.5 d开始连续 3d给予腹腔注射Syrosingopine[乳酸转运体抑制剂,剂量为 7.5 mg/(kg·d)];对照组单纯腹腔注射等…查看全部>>
Background Endometrial stromal cells undergo decidualization to further support pregnancy during implantation.Warburg-like glycolysis produces a large amount of lactic acid during decidualization.Objective To investigate the effects of lactic acid and metabolism on expression of placental angiogenesis and fetal growth in mice during early pregnancy.Methods CD1 female mice aged 6-8 weeks were selected in this study.Syrosingopine inhibitor(7.5 mg/[kg·d])was in…查看全部>>
金妮;陈书强;芦洁;王晓红
空军军医大学唐都医院妇产科生殖医学中心,陕西西安 710038空军军医大学唐都医院妇产科生殖医学中心,陕西西安 710038空军军医大学唐都医院妇产科生殖医学中心,陕西西安 710038空军军医大学唐都医院妇产科生殖医学中心,陕西西安 710038
临床医学
乳酸蜕膜组织胎盘促血管生成胎鼠生长
lactic aciddecidual tissueplacentaangiogenesisfetal growth
《解放军医学院学报》 2024 (8)
886-890,5
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