解放军医学院学报2024，Vol.45Issue(8)：898-903,6.DOI:10.12435/j.issn.2095-5227.2024.068
去泛素化酶调控骨改建相关信号通路的研究进展
Research advances in regulation of bone remodeling signaling pathway by deubiquitinating enzymes
摘要
Abstract
Deubiquitinating enzymes play a key role in maintaining the function and stability of cellular proteins by removing protein-linked ubiquitin chains.In recent years,it has been found that deubiquitination enzymes are involved in the regulation of bone remodeling during growth and development.To achieve functional balance in bone remodeling,it requires the participation of many signaling pathways,such as Wnt/β-catenin and BMP signaling pathways related to bone formation,and NF-κB and RANKL/RANK signaling pathways related to bone resorption.In this paper,the process of ubiquitin-deubiquitination is briefly introduced,and deubiquitination enzymes are involved in bone remodeling by regulating the function and stability of osteogenic and osteoclastic signaling pathway proteins.关键词
泛素化/去泛素化酶/骨形成/骨吸收/信号通路Key words
ubiquitination/deubiquitination enzyme/bone formation/bone resorption/signaling pathway分类
医药卫生引用本文复制引用
杨琳,段霏,李朋礼,陈琦,杨燕美,顾斌..去泛素化酶调控骨改建相关信号通路的研究进展[J].解放军医学院学报,2024,45(8):898-903,6.基金项目
国家老年疾病临床医学研究中心项目(NCRCG-PLAGH-2022017) （NCRCG-PLAGH-2022017）
