解放军医学院学报2024，Vol.45Issue(8)：909-912,封3,5.DOI:10.12435/j.issn.2095-5227.2024.063
急性胰腺炎肺损伤发病机制与程序性细胞死亡相关性的研究进展
Research advances in pathogenesis of lung injury in acute pancreatitis and programmed cell death
摘要
Abstract
Acute pancreatitis is a prevalent acute abdominal condition of the digestive system,which can lead to organ failure and be life-threatening in severe cases.Lung is the earliest and most frequently affected organ in severe acute pancreatitis,with limited treatment currently.While numerous studies have elucidated the pathogenic mechanisms underlying lung injury associated with acute pancreatitis,such as pancreatic enzyme theory,kinin theory,cytokine theory,and microcirculation theory,recent research has further enriched our understanding of the pathogenic mechanism.Programmed cell death actively regulates the stability of the body's internal environment and plays a crucial role in lung injury during acute pancreatitis.Apoptosis has been extensively studied in this context.Additionally,related studies have also identified necroptosis and pyroptosis as significant pathways leading to cell death in extrapancreatic organs during acute pancreatitis.Based on these findings regarding along with apoptosis,ferroptosis,pyroptosis,and necroptosis,this paper provides an overview of recent research results concerning programmed cell death related to lung injury in acute pancreatitis,aiming at offering theoretical references for future clinical applications.关键词
急性胰腺炎/肺损伤/凋亡/铁死亡/焦亡/坏死样凋亡Key words
acute pancreatitis/lung injury/apoptosis/ferroptosis/pyroptosis/necroptosis分类
医药卫生引用本文复制引用
吴浪,宁守斌,陈升鑫,陈德鑫,李明阳..急性胰腺炎肺损伤发病机制与程序性细胞死亡相关性的研究进展[J].解放军医学院学报,2024,45(8):909-912,封3,5.基金项目
首都临床特色诊疗技术研究及转化应用(Z221100007422061) （Z221100007422061）
