兰州大学学报（医学版）2024，Vol.50Issue(8)：54-64,11.DOI:10.13885/j.issn.1000-2812.2024.08.008
基于多组学探究STIP1在肝细胞癌中的表达特征及临床联系
A multi-omics-based exploration of the expression profile and clinicopathological association of STIP1 in hepatocellular carcinoma
摘要
Abstract
Objective To investigate the functional characteristics and clinical significance of stress induced phosphoprotein 1(STIP1)in hepatocellular carcinoma(HCC)based on multi-omics.Methods Based on the mRNA expression data of HCC from the public database,the expression of STIP1 in HCC tissues was ana-lyzed multidimensionally.The correlation between STIP1 and the abundance of tumor immune cell infiltra-tion,immune checkpoints and chemokines was analyzed,and a prognostic nomogram model was constructed based on the expression level of STIP1 and linicopathological characteristics.Results STIP1 was significantly up-regulated in hepatocellular carcinoma and meanningfully correlated with the histologic grade,pathological stage,T stage,N stage,M stage,body mass indes,α-fotoprotein expression level,as well as the degree of liver fibrosis.The high expression of STIP1 was significantly correlated with a poor survival prognosis of patients,and STIP1 showed good diagnostic efficacy for hepatocellular carcinoma.The expression level of STIP1 was significantly correlated with the abundance of CD4+T cells,T cell regulatory cells,monocytes,and infil-trated myeloid dendritic cells as well as with some immune checkpoints in hepatocellular carcinoma.STIP1 also correlated with sensitivity to chemotherapy and targeted therapies in some hepatocellular carcinomas.Conclusion STIP1 may be a prognostic marker and a potential predictive target in hepatocellular carcinoma,and there is a correlation between STIP1 and drug sensitivity in hepatocellular carcinoma.关键词
肝细胞癌/磷酸化应激诱导蛋白1/肝癌/预后标志物Key words
hepatocellular carcinoma/stress induced phosphoprotein 1/liver cancer/prognostic marker分类
医药卫生引用本文复制引用
张旭升,马勇新,柳科军,陈本栋..基于多组学探究STIP1在肝细胞癌中的表达特征及临床联系[J].兰州大学学报（医学版）,2024,50(8):54-64,11.基金项目
宁夏回族自治区自然科学基金重点资助项目(2023AAC02073) （2023AAC02073）
