热带亚热带植物学报2024，Vol.32Issue(5)：660-666,7.DOI:10.11926/jtsb.4821
光叶兔耳风石油醚部位化学成分和抗菌活性研究
Chemical Constituents from Petroleum Ether Fractions of Ainsliaea glabra and Antibacterial Activities
摘要
Abstract
In order to understand the chemical composition of Ainsliaea glabra,ten compounds were isolated from petroleum ether extraction fraction of 90% ethanol extract by silica gel,sephadex LH-20 gel column chromatography,semi-preparative high-performance liquid chromatography.Based on spectral data,their structures were identified as pinerenol diisovalerate(1),3β-hydroxy-11α,13-dihydro-costunolide(2),matricarin(3),taraxasteryl acetate(4),betulyl alcohol(5),27-hydroxyolean-12-en-28-oic acid(6),morolic acid acetate(7),(-)-loliolide(8),butyl benzoate(9),and E-phytenal(10).Compound 1 was a new structural compound.Compounds 3 and 7 were isolated from Ainsliaea genus for the first time.Compounds 2-7 and 9 were first reported in the A.glabra.The results of antibacterial activity test showed that compounds 1,2 and 8 had certain inhibitory effects on Staphylococcus aureus with MIC values of 31.2,25.0,and 21.8 μg/mL,and compounds 1 and 3 had potential inhibitory effect on Candida albicans with MIC values of 1.9 and 3.9 μg/mL,respectively.关键词
光叶兔耳风/化学成分/结构鉴定/抗菌活性Key words
Ainsliaea glabra/Chemical constituent/Structure identification/Antibacterial activity引用本文复制引用
姜国东,张森雨,刘亚凤,安振宇,吴秀丽,王芳,江志波,马晓莉,南泽东..光叶兔耳风石油醚部位化学成分和抗菌活性研究[J].热带亚热带植物学报,2024,32(5):660-666,7.基金项目
宁夏自然科学基金一般项目(2022AAC03292) （2022AAC03292）
北方民族大学研究生创新项目(YCX22164) （YCX22164）
宁夏自然科学基金优秀青年项目(2022AAC05041) （2022AAC05041）
宁夏重点研发项目(2021BEB04019)资助This work was supported by the General Program for Natural Science in Ningxia(Grant No.2022AAC03292),the Program for Graduate Innovation of North Minzu University(Grant No.YCX22164),the Program for Outstanding Youth of Natural Science in Ningxia(Grant No.2022AAC05041),and the Program for Key Research&Development in Ningxia(Grant No.2021BEB04019). （2021BEB04019）
