阿替普酶静脉溶栓联合序贯替罗非班治疗急性缺血性脑卒中患者的效果分析OA
Effect Analysis of Alteplase Intravenous Thrombolysis Combined with Sequential Tirofiban in the Treatment of Patients with Acute Ischemic Stroke
目的:探讨阿替普酶静脉溶栓联合序贯替罗非班治疗急性缺血性脑卒中患者的效果.方法:选取2021年10月—2022年 10月北京航天总医院神经内科收治的 80例急性缺血性脑卒中患者为研究对象,根据随机数字表法将其分为对照组和干预组,各 40例.对照组采用静脉注射阿替普酶溶栓治疗,干预组在对照组基础上采用联合序贯替罗非班治疗,比较两组的神经缺损程度、生活质量、认知功能水平、血液流变学指标及神经功能介质.结果:治疗 1周后,干预组美国国立卫生研究院卒中量表评分低于对照组,脑卒中专用生活质量量表、蒙特利尔认知评估量表评分均高于对照组,差异均有统计学意义(P<0.05).治疗 1周后,干预组红细胞沉降率、全血低切黏度、全血高切黏度、纤维蛋白原均低于对照组,差异均有统计学意义(P<0.05).治疗 1周后,干预组脑源性神经营养因子、胰岛素样生长因子-1均高于对照组,干预组神经生长因子低于对照组,差异均有统计学意义(P<0.05).结论:阿替普酶静脉溶栓联合序贯替罗非班治疗急性缺血性脑卒中可提升患者的生活质量及认知功能水平,改善神经缺损程度及神经功能介质指标,调节血液流变学指标.
Objective:To investigate the effect analysis of Alteplase intravenous thrombolysis combined with sequential Tirofiban in the treatment of patients with acute ischemic stroke.Methods:A total of 80 patients with acute ischemic stroke admitted to the Department of Neurology of Beijing Aerospace General Hospital from October 2021 to October 2022 were selected as the study objects,and were divided into a control group and an intervention group according to random number table method,with 40 cases in each group.The control group was treated with intravenous Alteplase thrombolytic therapy,and the intervention group was treated with sequential Tirofiban on the basis of the control group.The degree of nerve defect,quality of life,cognitive function level,hemorheology indexes and nerve function mediators of the two groups were compared.Results:One week after treatment,the scores of the National Institutes of Health Stroke Scale in the intervention group was lower than that in the control group,and the scores of the Stroke Specific Quality of Life scale and the Montreal Cognitive Assessment Scale were higher than those in the control group,with statistical significance(P<0.05).One week after treatment,the erythrocyte sedimentation rate,whole blood low shear viscosity,whole blood high shear viscosity and fibrinogen in the intervention group were lower than those in the control group,the differences were statistically significant(P<0.05).One week after treatment,brain-derived neurotrophic factor and insulin-like growth factor-1 in the intervention group were higher than those in the control group,and nerve growth factor in the intervention group was lower than that in the control group,with statistical significance(P<0.05).Conclusion:Alteplase intravenous thrombolysis combined with sequential Tirofiban in the treatment of acute ischemic stroke patients can improve the quality of life and cognitive function,improve the degree of nerve defect and neurofunctional mediators,and regulate the hemorheology indexes.
王超凡
北京航天总医院神经内科,北京 100076
临床医学
急性缺血性脑卒中阿替普酶静脉溶栓替罗非班
Acute ischemic strokeAlteplaseIntravenous thrombolysisTirofiban
《中国伤残医学》 2024 (017)
31-33,45 / 4
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