经鼻高流量加温湿化氧疗与无创机械通气对慢性阻塞性肺疾病急性加重期患者的疗效分析OA

Objective:To explore the therapeutic effect of high-flow nasal cannula oxygen therapy(HFNC)and non-invasive positive pressure ventilation(NPPV)on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 78 patients with AECOPD admitted to Jining City Yanzhou District People's Hospital from August 2021 to August 2023 were selected as the study objects.According to the random number table method,the patients were divided into a control group an and study group,with 39 cases in each group.The control group received NPPV and the study group received HFNC.The clinical efficacy,arterial blood gas analysis,sputum viscosity,inflammatory factors and occurrence of complications were compared between the two groups.Results:The total effective rate of the study group was 94.87%,which was higher than 76.92%of the control group,and the incidence of complications was 5.13%,which was lower than 20.51%of the control group,with statistical significances(P<0.05).After 1 week of treatment,the phlegm viscosity of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).After 1 week of treatment,the partial pressure of carbon dioxide in both groups was lower than before treatment,and the study group were lower than the control group,the blood oxygen partial pressure in both groups was higher than before treatment,and the study group was higher than the control group,the differences were statistically significant(P<0.05);the levels of procalcitonin,interleukin-6,tumor necrosis factor-α and C-reactive protein in the study group were lower than those in the control group,with statistical significances(P<0.05).Conclusion:Compared with NPPV,HFNC can better regulate arterial blood gas in patients with AECOPD,improve phlegm viscosity,control inflammation,and have fewer complications.