肿瘤预防与治疗2024，Vol.37Issue(9)：767-774,8.DOI:10.3969/j.issn.1674-0904.2024.09.005
超微血流成像与超声造影鉴别诊断早期子宫颈癌及癌前病变的对比研究
Comparative Study of Superb Microvascular Imaging and Contrast-En-hanced Ultrasound in the Differential Diagnosis of Early-Stage Cervical Cancer and Premalignant Lesions of Uterine Cervix
摘要
Abstract
Objective:To compare the value of superb mi-crovascular imaging(SMI)and contrast-enhanced ultrasound(CEUS)in the differential diagnosis of early cervical cancer and high-grade squamous intraepithelial lesions(HSIL).Methods:Retrospective analysis was conducted using SMI and CEUS quantitative analysis software on pathologically con-firmed cases of early cervical cancer[38 cases,average age:(49.4±10.2)years]and premalignant cervical lesions(HSIL)[24 cases,average age:(48.3±8.6)years].Differences in vascular index(Ⅵ)and 12 quantitative CEUS pa-rameters were analyzed.The diagnostic efficacy of Ⅵ and quantitative CEUS parameters in differentiating early cervical canc-er and HSIL was compared.Results:Compared with premalignant cervical lesion group,early-stage cervical cancer group showed significant increases in Ⅵ,peak intensity(PI),area under the curve(AUC),wash-in area under the curve,wash-out area under the curve(oAUC),wash-in rate(WiR),mean intensity and standard deviation(all P＜0.05).Ⅵ was highly correlated to CEUS quantitative parameters PI(r=0.784,P＜0.001),AUC(r=0.678,P＜0.001),oAUC(r=0.668,P＜0.001),WiR(r=0.671,P＜0.001),and mean intensity(r=0.635,P＜0.001).The diagnostic accuracy and sensitivity of Ⅵ were 87.4％and 97.4％,respectively,higher than those of CEUS quantitative parameters,while the specificity of Ⅵ was 62.7％,lower than those of CEUS quantitative parameters except for PI.Conclusion:SMI demonstra-ted comparable efficacy to CEUS in the differential diagnosis of early-stage cervical cancer and premalignant cervical lesions(HSIL).关键词
子宫颈癌/高级别上皮内病变/超微血流成像/超声造影/血管指数/时间强度曲线Key words
Cervical cancer/High-grade squamous intraepithelial lesion/Superb microvascular imaging/Contrast-en-hanced ultrasonography/Vascular index/Time-intensity curves分类
医药卫生引用本文复制引用
李晏杰,蒋卓霖,张杰,贾世军,唐益馨,罗欣怡,张国楠,朱熠..超微血流成像与超声造影鉴别诊断早期子宫颈癌及癌前病变的对比研究[J].肿瘤预防与治疗,2024,37(9):767-774,8.基金项目
中国博士后科学基金(编号:2023M730510) This study was supported by grants from China Postdoctoral Science Foundation(No.2023M730510). （编号:2023M730510）
