摘要
Abstract
Objective:To investigate the infection and the subtype distribution of cervical human papillomavirus(HPV)in infertile women,and the differences between them and ordinary women,in order to provide rationale for developing cervi-cal cancer screening and prevention strategies for special populations.Methods:816 infertile patients who met the inclusion criteria in the gynecology department of our hospital from January 2021 to December 2023 were retrospective collected as the study subjects.Ordinary women were matched as the control group in a 1∶1 ratio by age and visit time.Reverse line blot hybridization was used to detect HPV gene subtypes in cervical exfoliated cell samples of all study subjects,and statistical a-nalysis was conducted on HPV subtype infection.Results:The overall infection rate,single infection rate,multiple infection rate,and single high-risk subtype infection rate of HPV in the infertility group were significantly higher than those in the con-trol group of ordinary women(34.44％vs 23.77％,19.73％vs 15.44％,14.71％vs 8.33％,16.54％vs 12.50％),and the differences were statistically significant(x2=22.477,x2=5.179,x2=16.256,x2=5.376,all P＜0.05).There were no statistically significant differences in the distribution of single high-risk subtype infection,the distribution of single low-risk subtype infection,and the distribution of multiple infec-tions between the infertility group and the control group(x2=13.615,P=0.627;x2=1.133,P=0.951;x2=0.295,P=0.863).In the infertility women,there were statistically significant differences in the overall HPV infection rates among the under-25 year old group(25.00％),the 26-30 year old age group(40.36％),31-35 year old age group(31.76％)and the 36-40 year old age group(31.79％)(x2=7.541,P=0.042).In the age groups of 26～30,31～35 and 36～40,the overall HPV infection rates of infertile women were significantly higher than those of the ordinary women(40.36％vs 23.97％,31.7％vs 24.30％,31.79％vs 21.82％),and the differences were statistically significant(x2=17.508,x2=4.551,x2=4.270,all P＜0.05).Conclusion:The overall infection rate,single infection rate,multiple infection rate,and single high-risk subtype infection rate of HPV in infertile women are significantly higher than those in ordinary women.The HPV infection rate is highest in infertile women aged 26～30,indicating that HPV screening should be emphasized in the daily diagnosis and treatment of infertile patients.关键词
不孕症/人乳头瘤病毒/感染/基因亚型/相关性Key words
Infertility/Human papillomavirus/Infection/Gene subtypes/Correlation分类
医药卫生
