护理研究2024，Vol.38Issue(19)：3398-3402,5.DOI:10.12102/j.issn.1009-6493.2024.19.003
不同温度的间断性手足低温疗法对乳腺癌化疗致外周神经毒性的干预效果
Intervention effect of intermittent hand-foot hypothermia therapy with different temperatures on chemotherapy-induced peripheral neurotoxicity for breast cancer
摘要
Abstract
Objective:To evaluate the effect on chemotherapy-induced peripheral neurotoxicity(CIPN),hand and foot syndrome(HFS),and quality of life in breast cancer patients treated with intermittent hand and foot hypothermia at different temperatures.Methods:A total of 72 patients with breast cancer admitted to a tertiary grade A hospital in Tangshan city from Aug 2022 to May 2023 were selected as research subjects and randomly divided into study groups 1 and 2,with 36 cases in each group.During 15 minutes chemotherapy,before and after each infusion of taxoid drugs,both groups received intermittent hand and foot hypothermia therapy.Study group 1 and study group 2 wore-10～0℃ and-30～20℃ freezing gloves and foot covers,respectively.Differences in CIPN,HFS and quality of life,and hypothermia tolerability and safety were evaluated before intervention and after second,fourth and sixth cycles.Results:Frequency and severity of CIPN and HFS in study group 2 were lower than those in study group 1 after 4 and 6 cycles of intervention,and scores of physical function,emotional function,social function,general health,fatigue and insomnia were lower than those in study group 1,with statistical significance(P<0.05).There were no withdrawals from the study due to intolerance in either group.Conclusion:Intermittent low-temperature hand-foot hypothermia can effectively prevent the occurrence and severity of CIPN and HFS and improve patients' quality of life.关键词
间断性手足低温疗法/乳腺癌/化疗致外周神经毒性/手足综合征/生活质量Key words
intermittent hand-foot hypothermia therapy/breast cancer/chemotherapy-induced peripheral neuropathy,CIPN/hand-foot syndrome,HFS/quality of life引用本文复制引用
李冉,郭冬雪,周立芝,张子睿..不同温度的间断性手足低温疗法对乳腺癌化疗致外周神经毒性的干预效果[J].护理研究,2024,38(19):3398-3402,5.基金项目
2023年度河北省医学科学研究课题计划项目,编号:20231807 （）
2023年度唐山市人才资助项目,编号:A202301005 （）
