护理研究2024，Vol.38Issue(19)：3417-3422,6.DOI:10.12102/j.issn.1009-6493.2024.19.006
奶酪摄入量与骨关节炎关联性的双样本孟德尔研究
Associations of cheese intake with osteoarthritis:a Mendelian randomization study
夏晓琳 1王艳 2郭文静 1徐晓冰 1刘晔2
作者信息
- 1. 青岛大学护理学院,山东 266071
- 2. 山东大学齐鲁医院
- 折叠
摘要
Abstract
Objective:Using Mendelian randomization method,explore the causal relationship between cheese intake and the risk of osteoarthritis.Methods:Data from gene-wide association studies were used for analysis.The exposure factor was cheese intake,and the outcome variable was osteoarthritis.Mendelian randomization(MR)analysis was performed by IVW method,MR-Egger method and weighted median,and pleiotropy test,heterogeneity test and sensitivity analysis were performed.Results:The results of IVW and weighted median showed that cheese intake was a protective factor for osteoarthritis,and there was a negative causal association between them(P<0.05).The MR-Egger regression showed no statistically significant association between cheese intake and osteoarthritis(P=0.335).The results were tested for no heterogeneity or pleiotropy,and sensitivity analyses did not identify SNPs that significantly changed the overall causal relationship.Conclusion:Cheese intake is causally related to osteoarthritis.关键词
奶酪摄入量/骨关节炎/孟德尔随机化Key words
cheese intake/osteoarthritis/Mendelian randomization引用本文复制引用
夏晓琳,王艳,郭文静,徐晓冰,刘晔..奶酪摄入量与骨关节炎关联性的双样本孟德尔研究[J].护理研究,2024,38(19):3417-3422,6.
