奶酪摄入量与骨关节炎关联性的双样本孟德尔研究OA北大核心CSTPCD

Objective:Using Mendelian randomization method,explore the causal relationship between cheese intake and the risk of osteoarthritis.Methods:Data from gene-wide association studies were used for analysis.The exposure factor was cheese intake,and the outcome variable was osteoarthritis.Mendelian randomization(MR)analysis was performed by IVW method,MR-Egger method and weighted median,and pleiotropy test,heterogeneity test and sensitivity analysis were performed.Results:The results of IVW and weighted median showed that cheese intake was a protective factor for osteoarthritis,and there was a negative causal association between them(P<0.05).The MR-Egger regression showed no statistically significant association between cheese intake and osteoarthritis(P=0.335).The results were tested for no heterogeneity or pleiotropy,and sensitivity analyses did not identify SNPs that significantly changed the overall causal relationship.Conclusion:Cheese intake is causally related to osteoarthritis.