眼科学报2024，Vol.39Issue(7)：325-331,7.DOI:10.12419/24073004
小梁网泵衰竭在青光眼发病中的作用机制的研究进展
Research progress on the mechanism of trabecular meshwork pump failure in the pathogenesis of glaucoma
摘要
Abstract
Glaucoma,a group of optic nerve degenerative diseases,is characterized by papillary atrophy,visual field defects,and decreased vision.It is also the leading cause of irreversible blindness worldwide,significantly reducing patients'the quality of life of patients and posing considerable health economic burdens.However,the pathogenesis of glaucoma remains unclear,and promoting aqueous humor outflow to reduce intraocular pressure is the only treatment option available to slow disease progression.The main pathway for aqueous humor outflow is through the trabecular meshwork into Schlemm's canal and finally into the episcleral veins,highlighting the crucial role of the trabecular meshwork in regulating aqueous humor outflow and maintaining intraocular pressure balance.In recent years,there have been notable breakthroughs in in vivo and in vitro aqueous humor outflow measurement techniques and trabecular meshwork imaging technologies.Many studies suggest that the trabecular meshwork exhibits pressure-dependent rhythmic pulsation,playing a crucial role in the pulse-like outflow of aqueous humor.Unfortunately,in glaucoma,this pulsation weakens or even disappears as the disease progresses.This article focuses on the trabecular meshwork's pump theory and summarizes the latest research progress in aqueous humor outflow in glaucoma,exploring potential effective therapeutic strategies aimed at restoring trabecular meshwork function.This provides new insights for the clinical diagnosis and treatment of glaucoma.关键词
青光眼/小梁网/房水流出泵Key words
glaucoma/trabecular meshwork/aqueous outflow pump分类
医药卫生引用本文复制引用
车煜彤,蒋宇凡,吴彩清,杨扬帆..小梁网泵衰竭在青光眼发病中的作用机制的研究进展[J].眼科学报,2024,39(7):325-331,7.基金项目
中山大学高校基本科研业务费重点项目(23xkjc022).This work was supported by Fundamental Research Funds for the Central Universities,Sun Yat-sen University(23xkjc022). （23xkjc022）
