现代畜牧科技Issue(9)：39-43,5.DOI:10.19369/j.cnki.2095-9737.2024.09.011
基于WGCNA方法挖掘与猪皮下脂肪沉积相关的重要基因及通路
Identification of Key Genes and Pathways Involved in Subcutaneous Fat Deposition in Pigs Based on WGCNA Method
摘要
Abstract
Fat trait is one of the most important economic traits in pig industry.In this study,based on the gene expression data set GSE30343 of subcutaneous adipose tissue of lean pigs(Landrace pigs)and fatty pigs(Rongchang pigs)in the public GEO database.Weighted gene co-expression network analysis and other methods were used to explore key genes and signaling pathways related to pig fat deposition.The results showed that four gene co-expression modules were identified,among which the turquoise module was the most significant correlation module(r=0.94,P=5E-17)and eight key genes related to fat formation were identified.Eight key genes are GPAT,ACACA,ACLY,SCD,FASN,ACSS2,ME1 and SCD5,respectively.These genes are mainly involved in organic acid metabolism synthesis,fatty acid metabolism synthesis,AMPK and other signaling pathways.This study found some important genes related to fat deposition between different fat types of pigs,which provided potential candidate genes for genetic improvement of fat trait in pigs by molecular technology.关键词
脂肪沉积/皮下组织/WGCNA/基因Key words
lipidosis/subcutaneous tissue/WGCNA/gene分类
畜牧业引用本文复制引用
熊霞飞,陈强..基于WGCNA方法挖掘与猪皮下脂肪沉积相关的重要基因及通路[J].现代畜牧科技,2024,(9):39-43,5.基金项目
云南农业大学科研启动基金项目(KY2022-31) （KY2022-31）
