中风与神经疾病杂志2024，Vol.41Issue(9)：829-834,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0158
以皮质脑炎为主要表现的MOG抗体相关病4例并文献复习
Four cases of MOG antibody-associated disease with cortical encephalitis as the main manifestation and review of the literature
摘要
Abstract
Objective We report four cases of myelin oligodendrocyte glycoprotein(MOG)antibody-associated dis-ease(MOG-AD)with cortical encephalitis as the main manifestation.We analyse the clinical features and relevant ancil-lary tests,and review the literature in order to provide a reference basis for the proper clinical management of this disease.Methods The clinical manifestations,cerebrospinal fluid cytology,imaging,treatment and prognosis of four patients with MOG-AD with cortical encephalitis as the main manifestation,admitted to the Department of Neurology of the Affili-ated Hospital of Jining Medical University from October 2020 to February 2023,were retrospectively analyzed.The anti-MOG antibodies were detected by a cell-based assay(CBA).Results The four patients in this paper were aged 16-32 years and all presented with cortical encephalitis.Three of them started with seizures and one presented with his first sei-zure 15 d after headache and fever.The cranial MRI showed thickening of brain tissue in the cortical area and multiple ab-normal signal shadows in the sulcal pools,with relatively high signal on FLAIR images.Serum anti-MOG antibody tests were positive.The patients were treated with hormones and/or immunoglobulin and discharged,with two patients experi-encing relapses.Conclusion MOG-AD can have a predominantly cortical encephalitis phenotype,presenting with head-ache,fever and seizures.The initial diagnosis is easily made as"infective meningoencephalitis or meningitis",and cra-nial MRI often shows unilateral or bilateral cortical swelling;immunotherapy is effective,but some patients may experi-ence recurrence;for patients with cortical encephalitis who are poorly treated with anti-infective therapy,the disease needs to be alerted,and a"positive"serum MOG-IgG test can clarify the diagnosis.关键词
髓鞘少突胶质细胞糖蛋白/皮质脑炎/MOG抗体相关疾病/癫痫Key words
Myelin oligodendrocyte glycoprotein/Cortical encephalitis/MOG antibody-related disorders/epilepsy分类
医药卫生引用本文复制引用
史亚茹,褚旭,高明康,王金林,王琳..以皮质脑炎为主要表现的MOG抗体相关病4例并文献复习[J].中风与神经疾病杂志,2024,41(9):829-834,6.基金项目
济宁市重点研发计划项目(2022YXNS046) （2022YXNS046）
山东省中医药科技项目(2021M157) （2021M157）
