中风与神经疾病杂志2024，Vol.41Issue(9)：843-847,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0161
替罗非班对静脉溶栓后早期神经功能恶化的预防和治疗研究进展
Research progress on the prevention and treatment of early neurological deterioration after intravenous throm-bolysis with tirofiban
摘要
Abstract
At present,for acute ischemic stroke patients with onset time within 4.5 hours,intravenous thrombolysis is the preferred method for early reperfusion,but early neurological deterioration is prone to occur within 24 hours after thrombolysis,which is mainly related to the progress of ischemia.Early use of antiplatelet drugs may prevent or improve early neurological deterioration,but traditional antiplatelet drugs have a slow effect and related studies have shown a risk of bleeding.It is recommended to apply after 24 hours.However,24 hours after thrombolysis is a high-risk period for neu-rological deterioration,so it is necessary to find an antiplatelet drug that can be applied within 24 hours.Some studies have found that early use of tirofiban after intravenous thrombolysis can prevent early neurological deterioration.At the same time,for patients who have already experienced earlyneurological deterioration,the use of tirofiban can effectively improve their long-term prognosis.This article will elaborate on the research progress of the application of tirofiban in the prevention and treatment of early neurological deterioration after intravenous thrombolysis.关键词
急性缺血性脑卒中/静脉溶栓/替罗非班/早期神经功能恶化Key words
Acute ischemic stroke/Intravenous thrombolysis/Tirofiban/Early neurological deterioration分类
医药卫生引用本文复制引用
郑栋丹,胡风云..替罗非班对静脉溶栓后早期神经功能恶化的预防和治疗研究进展[J].中风与神经疾病杂志,2024,41(9):843-847,5.基金项目
吴阶平医学基金会临床专项科研资助基金(320.6750.16129) （320.6750.16129）
山西省重点研发计划项目(201603D321060) （201603D321060）
