中国动物检疫2024，Vol.41Issue(9)：80-88,9.DOI:10.3969/j.issn.1005-944X.2024.09.016
猪繁殖与呼吸综合征疫苗研究进展
Research Progress on Vaccines of Porcine Reproductive and Respiratory Syndrome
于晓璐 1李扬 1孙化露 1侯玉超 1楚电峰1
作者信息
- 1. 青岛易邦生物工程有限公司,兽医公共卫生安全全国重点实验室,山东青岛 266100
- 折叠
摘要
Abstract
Porcine reproductive and respiratory syndrome(PRRS)is a highly contagious disease caused by porcine reproductive and respiratory syndrome virus(PRRSV),posing a serious threat to sustainable development of pig industry.A variety of PRRS vaccines have been globally developed,contributing to the control of the disease to a certain extent.The currently widely used vaccines mainly include traditional live vaccines and inactivated vaccines,but the former is poor for cross protection for different genotype of strains,and with the risk of virus recombination and mutation,while the latter has low immunogenicity and should be assisted by adjuvants and needs repeated immunization.Further researches and clinical experiments should be conducted on new technical vaccines such as chimeric vaccines,gene deletion vaccines,subunit vaccines,live-vector vaccines and nucleic acid vaccines,although they have good safety and immune efficacy.In the future,with continuous progress of new techniques,better effectiveness and safety will be provided by PRRS vaccines.Here,the application and latest research progress of traditional or new vaccines were reviewed,aiming to provide a reference for PRRS prevention and control and vaccine development.关键词
猪繁殖与呼吸综合征/活疫苗/嵌合疫苗/亚单位疫苗/核酸疫苗Key words
PRRS/live vaccine/chimeric vaccine/subunit vaccine/nucleic acid vaccine分类
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于晓璐,李扬,孙化露,侯玉超,楚电峰..猪繁殖与呼吸综合征疫苗研究进展[J].中国动物检疫,2024,41(9):80-88,9.
