中国临床药理学杂志2024，Vol.40Issue(18)：2695-2698,4.DOI:10.13699/j.cnki.1001-6821.2024.18.018
Lp-PLA2、PAR-2、AOPP联合检测对PCI术后支架内再狭窄的预测价值
Predictive values of combined detection of Lp-PLA2,PAR-2 and AOPP for in-stent restenosis after PCI
摘要
Abstract
Objective To investigate the relationship between the combined detection of lipoprotein-associated phospholipase A2(Lp-PLA2),protease activated receptor 2(PAR-2),and advanced oxidation protein products(AOPP)and the occurrence of in-stent restenosis after percutaneous coronary intervention(PCI),as well as its predictive value.Methods Patients with coronary heart disease after PCI were selected as the study objects.Group Ⅰ was the group without in-stent restenosis and group Ⅱ was the group with in-stent restenosis.The expressions of Lp-PLA2,PAR-2 and AOPP were detected by enzyme-linked immunosorbent assay(ELISA),and the predictive value and independent risk factors of these gene expression changes and the risk of in-stent restenosis were analyzed by receiver operating characteristic(ROC)analysis and binary logistic regression analysis.Results The blood Lp-PLA2 levels in group Ⅰ and group Ⅱ after 1 year follow-up after stenting were(190.24±33.67)and(256.14±37.68)ng·mL-1;PAR-2 levels were(1.41±0.38)and(1.95±0.43)ng·L-1,respectively;the AOPP levels were(47.25±4.62)and(58.76±4.86)μmol·L-1,respectively,and the differences were statistically significant(all P＜0.001).ROC analysis results showed that the truncation values of Lp-PLA2,PAR-2 and AOPP were 201.32 ng·mL-1,1.50 ng·mL-1 and 49.37 μmol·L-1,respectively.The area under the curve(AUC)was significantly higher than that detected alone(all P＜0.001).Binary logistic regression analysis shows that the independent risk factors for in-stent restenstenosis after PCI were Lp-PLA2 ≥ 201.32 ng·mL-1,PAR-2≥1.50 ng·L-1,AOPP ≥49.37 μmol·L-1 and LDL-C≥3.03 mmol·L-1,respectively(all P＜0.05).Conclusion The occurrence of in-stent restenosis after PCI is closely related to the increase in Lp-PLA2,PAR-2 and AOPP expression.关键词
脂蛋白相关磷脂酶A2/经皮冠状动脉介入术/支架内再狭窄/蛋白酶激活受体2/晚期氧化蛋白产物Key words
lipoprotein-associated phospholipase A2/percutaneous coronary intervention/in-stent restenosis/percutaneous coronary intervention/advanced oxidation protein products分类
医药卫生引用本文复制引用
侯小东,张鹏,王新宽,丁凡,移康,尤涛..Lp-PLA2、PAR-2、AOPP联合检测对PCI术后支架内再狭窄的预测价值[J].中国临床药理学杂志,2024,40(18):2695-2698,4.基金项目
甘肃省自然科学基金资助项目(21JR1RA027) （21JR1RA027）
