中国临床药理学杂志2024，Vol.40Issue(18)：2747-2751,5.DOI:10.13699/j.cnki.1001-6821.2024.18.029
miR-135b在消化系统恶性肿瘤中的研究现状
Research status of miR-135b in malignant tumors of the digestive system
摘要
Abstract
MicroRNAs(microRNAs,miRNAs)are a class of endogenous,single-stranded,short and highly conserved non-coding RNAs.miR-135b,as a member of miRNAs,is aberrantly expressed in digestive malignancies.Its mechanism of action involves a variety of target genes and participates in tumorigenesis and development by regulating cell proliferation,metastasis,and drug resistance.Clinical studies have shown that high expression of miR-135b is associated with poor patient prognosis and decreased survival.As a potential biomarker,miR-135b may be useful in the diagnosis,prognostic assessment,and therapeutic monitoring of malignant tumors of the digestive system.Therefore,miR-135b and its regulated pathways may become future therapeutic targets and provide new ideas for the treatment and management of tumor patients.关键词
微小RNA/miRNA-135b/消化系统肿瘤Key words
microRNA/microRNA-135b/tumors of the digestive system分类
医药卫生引用本文复制引用
何钰洁,陈佳,夏琪,陈文,殷佩浩..miR-135b在消化系统恶性肿瘤中的研究现状[J].中国临床药理学杂志,2024,40(18):2747-2751,5.基金项目
上海市普陀区卫生健康系统临床特色专科建设基金资助项目(2021tszk01) （2021tszk01）
上海中医药大学科技发展基金资助项目(23kfl084) （23kfl084）
