中国临床药理学杂志2024，Vol.40Issue(19)：2766-2770,5.DOI:10.13699/j.cnki.1001-6821.2024.19.002
吲哚布芬联合氯吡格雷治疗老年冠心病PCI术后患者的临床研究
Clinical trial of indobufen combined with clopidogrel in the treatment of elderly patients with coronary heart disease after PCI
摘要
Abstract
Objective To observe the effects of indobufen tablets combined with clopidogrel tablets on levels of serum myocardial injury indexes and incidence of major adverse cardiovascular events(MACE)in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods The elderly patients with coronary heart disease after PCI were divided into treatment group[clopidogrel 75 mg(qd)combined with indobufen 200 mg(qd)]and control group[clopidogrel 75 mg(qd)combined with aspirin 100 mg(qd)]according to cohort method.All patients were treated for 3 months.The total effective rate,serum myocardial injury indexes[N terminal pro B type natriuretic peptide(NT-proBNP),cardiac troponin Ⅰ(cTn Ⅰ)],coagulation-fibrinolysis indexes[fibrinogen(FIB),prothrombin time(PT),antithrombin Ⅲ(AT-Ⅲ)]and platelet function indexes[platelet distribution width(PDW)]were compared between two groups.Occurrence of bleeding events and MACE within 6 months were compared between the two groups.The safety was evaluated.Results There were 32 cases in control group and 32 cases in treatment group.After treatment,the total effective rates in treatment group and control group were 93.75％(30 cases/32 cases)and 78.13％(25 cases/32 cases),without significant difference(P＞0.05).After treatment,NT-proBNP levels in treatment group and control group were(202.65±30.77)and(283.52±31.42)pg·mL-1,cTn Ⅰ levels were(0.06±0.01)and(0.12±0.03)ng·mL-1,FIB levels were(3.17±0.51)and(3.84±0.59)g·L-1,PT were(15.87±1.23)and(14.92±1.35)s,AT-Ⅲ levels were(138.95±14.18)％and(125.17±14.96)％,PDW were(17.04±2.04)％and(19.13±2.32)％,the differences were statistically significant(all P＜0.05).The incidences of bleeding events in treatment group and control group were 6.25％and 15.63％,adverse drug reactions were 9.38％and 15.63％,respectively,the differences of above indexes were statistically significant between two groups(all P＞0.05).The total incidences of MACE in treatment group and control group were 6.25％and 25.00％,respectively(P＜0.05).Conclusion Indobufen tablets combined with clopidogrel tablets can reduce levels of serum myocardial injury indexes in elderly patients with coronary heart disease after PCI,improve coagulation-fibrinolysis function and reduce the incidence of MACE.关键词
吲哚布芬片/氯吡格雷片/老年冠心病/经皮冠状动脉介入治疗/心肌损伤/主要不良心血管事件Key words
indobufen tablet/clopidogrel tablet/elderly coronary heart disease/percutaneous coronary intervention/myocardial injury/major adverse cardiovascular event分类
医药卫生引用本文复制引用
方慧瑾,贺骞,刘善湖,汪霞,俞冰荟..吲哚布芬联合氯吡格雷治疗老年冠心病PCI术后患者的临床研究[J].中国临床药理学杂志,2024,40(19):2766-2770,5.基金项目
上饶市指导性科技计划基金资助项目(2022CZDX22) （2022CZDX22）
